Immunology of the Influenza A H1N1 infection

Authors

  • Odalys Orraca Castillo Especialista de Primer Grado en Inmunología, Instructora. Centro Provincial de Higiene, Epidemiología y Microbiología. Pinar del Río.
  • Laura Margarita González Valdés Especialista de Primer Grado en Medicina General Integral, Master en Enfermedades Infecciosas, Instructora, Centro Provincial de Higiene, Epidemiología y Microbiología. Pinar del Río.
  • María de la Caridad Casanova Moreno Especialista de Segundo Grado en Medicina General Integral, Master en Longevidad Satisfactoria, Profesora Auxiliar. Centro Provincial de Higiene, Epidemiología y Microbiología. Pinar del Río.
  • Daimarelis Guerra del Valle Especialista de Primer Grado en Medicina General Integral, Instructora, Centro Provincial de Higiene, Epidemiología y Microbiología. Pinar del Río.
  • José G. Sanabria Negrín Doctor en Ciencias Biológicas. Especialista de Segundo Grado en Histología. Profesor Auxiliar. Universidad de Ciencias Médicas. Pinar del Río.

Abstract

An update about the virology and immunology of the Influenza A H1N1 infection is made.  The first epidemic of the XXIth century was addresses by WHO on June 9th, 2009.  H1N1 is a new virus of the Influenza A, showing increased infection, thereby influencing on the spreading speed of the infection among different countries leading to high morbidity and mortality.  The viral genome (RNA), being formed of 8 fragments, works for a defective viral replication and on the process of antigenic flux and change, having a genetic rearrangement causing the appearance of new viral strains.  The inefficient induction of interferon, the weak role of neutralizing antibodies in the prime-infection, and the release of pro-inflammatory cytokines, added to the bacterial superimposed infections will condition the high morbidity and mortality that are increased in certain comorbid conditions of the infected individuals.  Changes occurring on viral antigens avoid the reconnaissance of the virus by the immune system, then the difficulty to make a proper vaccine.   Understanding the immunopathology of this infection, so as the divulgation of this information to the scientific community, are the initial steps for the taking of decisions to favor the avoiding of the infection spreading.

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Published

2010-03-19

How to Cite

1.
Orraca Castillo O, González Valdés LM, Casanova Moreno M de la C, Guerra del Valle D, Sanabria Negrín JG. Immunology of the Influenza A H1N1 infection. Rev Ciencias Médicas [Internet]. 2010 Mar. 19 [cited 2025 Oct. 12];14(1):308-22. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/620

Issue

Vol. 14 No. 1 (2010)

Section

REVIEW ARTICLES

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