Interaction between hidradenitis suppurativa and systemic lupus erythematosus: inflammatory and autoimmune mechanisms
Keywords:
HIDRADENITIS SUPURATIVA; LUPUS ERITEMATOSO SISTÉMICO; AUTOINMUNIDAD., HIDRADENITIS SUPPURATIVA; LUPUS ERYTHEMATOSUS, SYSTEMIC; AUTOIMMUNITY., HIDRADENITE SUPURATIVA; LÚPUS ERITEMATOSO SISTÊMICO; AUTOIMUNIDADE.Abstract
Introduction: systemic lupus erythematosus (SLE) and hidradenitis suppurativa (HS) are chronic inflammatory conditions that could have an immunological interrelationship. HS presents with painful abscesses and nodules in intertriginous areas, whereas SLE is a multisystem disease characterized by skin eruptions, joint involvement, and physical alterations.
Objective: to describe the immunological mechanisms, predisposing factors, the clinical manifestations of HS and SLE, and the possible intersections that could guide future research and therapies.
Methods: aAn integrative bibliographic analysis of publications from 2015 to 2024 was performed, selected from scientific databases such as PubMed, BVS, SciELO, and Elsevier. Studies addressing pathophysiology, immunological interaction, and potential relationships between HS and SLE were incorporated.
Results: findings indicate that proinflammatory cytokines such as TNF-α, IL-17, and IL-23 play a crucial role in both conditions, promoting chronic inflammation and aberrant immune activation. These similarities in the inflammatory cascade could justify the co-occurrence of both diseases in certain patients and propose new avenues of study regarding their pathophysiological link.
Conclusion: contemporary research indicates that hidradenitis suppurativa and systemic lupus erythematosus share inflammatory mechanisms that could be involved in their etiology. This underscores the importance of combined diagnostic and therapeutic strategies to optimize the management of patients with both conditions. Additional investigations are advised to corroborate these links and develop more effective therapeutic approaches focused on common immunological pathways.
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