Incidence and Tendency of Cervical-Uterine Lesions in Pinar del Río 10-to-14-year-old women, 2003-2012

Authors

  • José Guillermo Sanabria Negrín Universidad de Ciencias Médicas de Pinar del Río
  • Víctor Enrique Salgueiro Medina Hospital General Docente “Abel Santamaría Cuadrado”.
  • Magalys Brígida Abreu Mérida Hospital General Docente "Abel Santamaría Cuadrado".
  • Agustín Lemus Sarracino Hospital General Docente "Abel Santamaría Cuadrada"
  • Raydel Marrero Fernandez Departamento de Morfofisiología, Universidad de Ciencias Médicas

Keywords:

Adolescent, Cervical intraepithelial neoplasia, Neoplasms, Uterine cervical neoplasms.

Abstract

Introduction: malignant and pre-malignant lesions have been localized in women less than 25 years, but the exact enormity of the problem in Pinar del Río is not known.
Objective: to evaluate the tendency and incidence of malignant and pre-malign cervical lesions in Pinar women less than 25 years old according to demographic characteristics, in the period 2003-2012.
Material and method: a retrospective, cross-sectional study was carried out, in order to know the annual incidence of malign and pre-malign cervical lesions in Pinar women younger than 25 years. The sample comprised the results of biopsies made of those women in that period.
Results: the annual incidence in 10,000 women from 10-24 years old was 8.8 for CIN1, 3.1 for CIN2, 1.6 for CIN3 + CIS (carcinoma in situ), 0.07 for de micro-invasive, 0.03 for the invasive Ib, and 0.02 for the invasive stage II. Stages over neither epidermoidal nor endocervical adenocarcinomas were detected. The annual incidence in each lesion proved increasing particularly for NIC1 cases. Out of 1,198 biopsies made on this age group, only 10 invasive epidermoidal carcinomas were detected in ten years, 0.7 annually, with a proportion of 5.8 per 1,000 women between 10-24 years of age.
Conclusions: the tendency of malignant lesions detected in this group would not justify starting the cytological screening before the 25 years of age, since the cost would high and the benefit would be minimal.

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Author Biographies

José Guillermo Sanabria Negrín, Universidad de Ciencias Médicas de Pinar del Río

Especialista de II Grado Histología, Profesor Auxiliar. Doctor en Ciencias Biológicas. Dirección Provincial de Ciencia y Tecnología.

Víctor Enrique Salgueiro Medina, Hospital General Docente “Abel Santamaría Cuadrado”.

Especialista de I y II Grado en Ginecología y Obstetricia, Máster en Atención Integral a la Mujer. Jefe de la Consulta Provincial de Patología de Cuello

Magalys Brígida Abreu Mérida, Hospital General Docente "Abel Santamaría Cuadrado".

Especialista II Grado en Ginecología y Obstetricia, Consulta Provincial de Patología de Cuello

Agustín Lemus Sarracino, Hospital General Docente "Abel Santamaría Cuadrada"

Especialista de I y II Grado en Anatomía Patológica. Prof. Auxiliar, Máster en Medios Diagnosticos.

Raydel Marrero Fernandez, Departamento de Morfofisiología, Universidad de Ciencias Médicas

Médico General. Residente 2do Año de Histología

References

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010 Dec 15;127(12):2893-917. En: http://onlinelibrary.wiley.com/doi/10.1002/ijc.25516/full. 15-02-2011

2. Insinga RP, Dasbach EJ, Elbasha EH. Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: a critical and systematic review of the literature in the development of an HPV dynamic transmission model. BMC Infectious diseases 2009; 9:119. And in : http://www.biomedcentral.com/1471-2334/9/119. Acceso: 15-01-2010

3. Solomon D, Davey D, Kurman R, Moriarty A, O´Connor D, Prey M. et al. The 2001 Bethesda System. Terminology for reporting results of cervical cytology. JAMA 2002 Apr 24; 287(16): 2114-2119 En: http://screening.iarc.fr/atlascytobeth.php?cat=A0&lang=1

4. Moore K, Cofer A, Elliot L, Lanneau G, Walker J, Gold MA. Adolescent cervical dysplasia: histologic evaluation, treatment, and outcomes. Am J Obstet Gynecol. 2007 Aug;197(2):141.e1-6. EN: http://www.sciencedirect.com/science/article/pii/S0002937807003973. Acceso 14-11-2007

5. Moore K, Cofer A, Elliot L, Lanneau G, Walker J, Gold MA. Adolescent cervical dysplasia: histologic evaluation, treatment, and outcomes. Am J Obstet Gynecol. 2007 Aug; 197(2):141.e1-6: en: http://www.sciencedirect.com/science/article/pii/S0002937807003973. Acceso 14-01-2008

6. Moscicki AB, Shiboski S, Hills NK, Powell KJ, Jay N, Hanson EN, Miller S, Canjnura-Clayton LK, Farhat S, Broering JM, Darragh TM. Regression of low-grade squamous intra-epithelial lesions in young women. Lancet 2004; 364 : 1678-83. En: http://linkinghub.elsevier.com/retrieve/pii/S0140673604173546. Acceso 24-05-2006

7. Moscicki AB. Management of adolescents with abnormal cytology and histology for OBGYN Clinics of North America. Obstet Gynecol Clin North Anm 2008 Dec 35 (4): 633-x. en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766533/?tool=pmcentrez. Acceso 14-03-13

8. Sankaranarayanan R, Bhatla N, Gravitt PE, Basu P, Esmy PO, Ashrafunnessa KS, Ariyaratne Y, Shah A, Nene BM. Human papillomavirus infection and cervical cancer prevention in India, Bangladesh, Sri Lanka and Nepal. Vaccine. 2008 Aug 19;26 Suppl 12:M43-52 en: http://www.sciencedirect.com/science/article/pii/S0264410X0800577X. Acceso 13-01-2009

9. Winer RL, Lee SK, Hughes JP, Adam DE, Kiviat NB, Koutsky LA. Genital Human Papillomavirus Infection: Incidence and Risk Factors in a Cohort of Female University Students. Am J Epidemiol 2003; 157 (3): 218-226. En: http://aje.oxfordjournals.org/content/157/3/218.long. Acceso. 20-04-05

10. Case AS, Rocconi RP, Straughn JM Jr, Wang W, Roark K, Waltman EE, Huh WK. Cervical intraepithelial neoplasia in adolescent women: incidence and treatment outcomes. Obstet Gynecol. 2006 Dec;108 (6):1369-74. En: http://journals.lww.com/greenjournal/Abstract/2006/12000/Cervical_Intraepithelial_Neoplasia_in_Adolescent.6.aspx Acceso 30-03-08.

11. Guido R. Human papillomavirus and cervical disease in adolescents. Clin Obstet Gynecol. 2008 Jun; 51 (2):290-305. En: http://journals.lww.com/clinicalobgyn/Abstract/2008/06000/Human_Papillomavirus_and_Cervical_Disease_in.13.aspx. Acceso 24-09-2009

12. del Pino M, Torne A, Alonso I, Mula R, Masoller N, Fuste V, Ordi J. Colposcopy prediction of progression in human papillomavirus infections with minor cervical lesions. Obstet Gynecol. 2010 Dec;116(6):1324-31. http://journals.lww.com/greenjournal/Abstract/2010/12000/Colposcopy_Prediction_of_Progression_in_Human.14.aspx. Acceso 14-07-2011

13. Cabeza CE. Programa Nacional de Diagnóstico Precoz del Cáncer Cérvicouterino.

La Habana: Editorial de Ciencia Médicas; 2001, Actualizado en 2011 (en prensa)

14. Michala L, Argyn E, Tsimplaki E, Tsitsika A, Bakoula C, Antsaklis A, Panotopoulou E. Human papiloma virus infection in sexually active adolescent girls. Gynecologic Oncology 2012; 126 (2): 207-210 en: http://www.sciencedirect.com/science/article/pii/S0090825812003307. Acceso 15-03-13.

15. Hwang LY, Lieberman JA, Ma Y, Farhat S, Moscicki AB. Cervical ectopy and the acquisition of human papillomavirus in adolescents and young women. Obstet Gynecol 2012 Jun; 119 (6): 1164-70. En: http://www.ncbi.nlm.nih.gov/pubmed/?term=doi:+10.1097/AOG.0b013e3182571f47. Acceso 15-03-13

16. Moscicki AB, Ma Y, Wibbelsman C, Powers A, Darragh TM, Nozzari S, Shaber R, Shiboski S. Risks for cervical intraepithelial neoplasia-3 among adolescent and young women with abnormal cytology. Obstet Gynecol 2008 Dec; 112 (6): 1335-1342. En: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735396/?tool=pubmed. Acceso 15-05-2009

17. Rodríguez AC, Schiffman M, Herrero R, Wacholder S, Hildesheim A, Castle PE, Solomon D, Burk R. Rapid clearance of HPV and implications for clinical focus on persistent infections. JNCI 2008; 100(7): 513-517. En: http://jnci.oxfordjournals.org/content/100/7/513.full. Acceso 04-09-2009

18. Daudinot Cos CE, Rodríguez Spínola A, Sáez Cantero Vde la C, De la Torre Jiménez AI. Caracterización de las lesiones intra-epiteliales cervicales de alto grado en adolescentes y mujeres jóvenes. Medisur 2011; 9 (5). EN: http://www.medisur.sld.cu/index.php/medisur/article/view/1745. Acceso 17-04-2012

19. Zhao C, Kalposi-Novak P, Austin M. Follow-up findings in young females with high-grade squamous intraepithelial lesion Papanicolaou test results. Arch Pathol Lab Med 2011; 135:365-364 in doi:10.1016/j.ygyno.2009.05.019 en: http://www.archivesofpathology.org/doi/pdf/10.1043/2010-0121-OA.1 Acceso 15-03-13

20. Moscicki AB, Cox JT. Practice improvement in cervical screening and management (PICSM): Symposium on Management of Cervical Abnormalitis in Adolescents and Yong Women. J Low Genit Tract Dis. 2010 Jan 14 (1): 73-80. En: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058950/ Acceso 24-07-2011

21. Martínez Chang YM, Sarduy Nápoles M. Rev Cubana Invest Bioméd. 2006; 23 (1) : en : http://scielo.sld.cu/scielo.php?pid=S0864-03002006000100001&script=sci_arttext&tlng=en. Acceso 23-01-07

22. Hilton S, Smith E. “I thought cancer was one of those random things. I didn´t know cancer could be caught…” Adolescent girls´understanding and experiences of the HPV programme in the UK. Vaccine 2011 June 10; 29 (26): 4409-4415. En: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176894/. Acceso: 15-03-13

23. Ho GY, Einstein MH, Romney SL, Kadish AS, Abadi M, Mikhail M, Basu J, Thysen B, Reimers L, Palan PR, Trim S, Soroudi N, Burk RD; Albert Einstein Cervix Dysplasia Clinical Consortium. Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting. J Low Genit Tract Dis. 2011 Oct;15(4):268-75. doi: 10.1097/LGT.0b013e3182216fef. en: http://journals.lww.com/jlgtd/Abstract/2011/10000/Risk_Factors_for_Persistent_Cervical.4.aspx. Acceso 15-03-13

Published

2014-02-27

How to Cite

1.
Sanabria Negrín JG, Salgueiro Medina VE, Abreu Mérida MB, Lemus Sarracino A, Marrero Fernandez R. Incidence and Tendency of Cervical-Uterine Lesions in Pinar del Río 10-to-14-year-old women, 2003-2012. Rev Ciencias Médicas [Internet]. 2014 Feb. 27 [cited 2025 Sep. 3];18(1):4-13. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/1249

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ORIGINAL ARTICLES