Rhabdomyolysis caused by propofol leads to acute renal failure
Keywords:
Rhabdomyolysis/complications, Renal insufficiency/therapy, Propofol.Abstract
Introduction: One of the most feared complications of rhabdomyolysis is acute renal failure. Renal injury is caused by acute tubular necrosis resulting from myoglobinuria. It usually begins to improve within 15 days, although it can also lead to death or last longer. A wide variety of sedatives are currently available in intensive care, including propofol. In propofol infusion syndrome, its pathophysiology is still unknown; it is characterized by heart failure, rhabdomyolysis, metabolic acidosis and acute renal failure. In critical care, acute renal failure is a frequent condition in the context of multiple conditions; however, it is infrequently related to the use of sedatives.
Case presentation: this was a patient admitted to the Intensive Care Unit for severe pneumonia, requiring invasive mechanical ventilation. He developed acute renal failure due to rhabdomyolysis, secondary to the use of propofol. He received treatment with renal replacement therapy and full recovery at discharge.
Conclusions: the case presented shows rhabdomyolysis as a cause of acute renal failure, which is not always acute renal failure, not always prevented, from the presence of myoglobinuria in urine, blood and themyoglobinuria in urine, blood and the elevation of enzymes (creatine kinase, lactate dehydrogenase),
lactate dehydrogenase). The use of propofol implies not to pass the patched doses, and rhabdomyolysis should be recognized among its possible adverse effects.
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