Chronic neurocryptococcosis in an immunocompetent patient
Keywords:
Cryptococcosis, Immunocompetence, Meningoencephalitis, Miconazole.Abstract
A patient having no history or evidences of immune disorders, presented chronic meningoencephalitis. This patient was admitted three times with different diagnosis in a 10-month period. The diagnosis of neurocryptococcosis was confirmed by means of studies with India ink stain and mycological culture of cerebrospinal fluid, no other localization of fungus was found. The patient was discharged after the treatment with Amphotericin B and miconazole along with immunological follow-up to 2014; he was recently discharged after 10 years, definitely excluding an acquired immunocompetence.Downloads
References
1. Georgi A, Schneemann M, Tintelnot K, Calligaris-MaibachRC, Meyer S, Weber R, et al. Cryptococcus gattiimeningoencephalitisin an immunocompetent person 13 monthsafterexposure. Infection [Internet] 2009 [citado 12 Feb 2014]; 37: [aprox. 3 p.]. Disponible en : http://download.springer.com/static/pdf/57/art%253A10.1007%252Fs15010-008-8211-z.pdf?auth66=1405258006_ba9ec3c5e2c2900bce38e857d329ec62&ext=.pdf
2. Da Silva BK, Freire AK, Bentes Ados S, Sampaio Ide L, Santos LO, Dos Santos MS, et al. Characterization of clinical isolates of the Cryptococcus neoformans-Cryptococcus gattii species complex from the Amazonas State in Brazil. Rev Iberoam Micol [Internet]. 2012 [citado 20 Ene 2014]; 29(1): [aprox. 4 p.]. Disponible en: http://www.reviberoammicol.com/2012-29/040043.pdf
3. Gutierrez EL, Valqui W, Vilchez L, Evangelista L, Crispin S, TelloM, et al. Cryptococcus gattii meningoencephalitis in an HIV-negativepatient from the Peruvian Andes. RevSocBrasMedTrop [Internet]. 2010 [citado 12 Feb 2014]; 43(4): [aprox. 3 p.]. Disponible en: http://www.scielo.br/scielo.php?pid=S0037-86822010000400029&script=sci_arttext
4. Hagen F, Boekhout T. The Search for the Natural Habitat of Cryptococcus gattii. Mycopathologia [Internet]. 2010 [citado 20 Ene 2014]; 170: [aprox. 3 p.]. Disponible en: http://link.springer.com/article/10.1007%2Fs11046-010-9313-6#page-1
5. Botero J, Ruiz J, Márquez S. Criptococosis en un paciente inmunocompetente. Informe de um caso. Revista CES MEDICINA [Internet]. 2003 Ene-Jul [citado 20 Ene 2014]; 17(1): [aprox. 8 p.]. Disponible en: http://revistas.ces.edu.co/index.php/medicina/article/view/517
6. EscandónP, de Bedout C, Lizarazu J, Agudelo CI, Tobón A, Bello S, et al. Cryptococcosis in Colombia: Results of the national surveillance program for the years 2006-2010. Biomédica [Internet] 2012 Jul/Sept [citado 20 Ene 2014]; 32(3): [aprox. 10 p.]. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-41572012000300009&lang=pt
7. Harris J, Lockhart S, Chiller T. Cryptococcus gattii: where do we go from here?. Med Mycol. 2012 Feb;50(2):113-29.
8. Bava A, Zuliani M. Desarrollo de Cryptococcus neoformans en medios de cultivo empleados para diagnostico bacteriologico. Acta Bioquim Clin Latinoam [Internet]. 2009 [citado 20 Ene 2014]; 43(2): [aprox. 5 p.]. Disponible en: http://www.scielo.org.ar/scielo.php?pid=S0325 -29572009000200003&script=sci_arttext
9. Springer DJ, Phadke S, Billmyre B, Heitman J. Cryptococcus gattii, no longer an accidental pathogen?. Curr Fangal Infect Rep [Internet] 2012 Dec [citado 15 Ene 2014]; 6(4): [aprox. 12 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521508/
10. Da Silva A,Goldani LZ. Neuroimaging Features of Immune Reconstitution Inflammatory Syndrome in a Patient with AIDS Successfully Treated for Neurocryptococcosis. Case Rep Radiol [Internet] 2013 [citado 20 Ene 2014]; 2013: [aprox. 10 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773889/
11. Zaragoza O, Cuesta I, Rodríguez Tudela JL, Cuenca Estrella M, Buitrago MJ. High-Resolution Melting Analysis for Identification of the CryptocGagooccus neoformans-Cryptococcus gattii Complex. J ClinMicrobiol [Internet] 2011 Oct [citado 15 Ene 2014]; 49(10): [aprox. 7 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187306/
12. Rocha KC, Pinhal C, Cavalcanti S, Vidal M, Toscano M, Moraes Vasconcelos D, et al. Lymphocyte transformation assay for C neoformans antigen is not reliable for detecting cellular impairment in patients with Neurocryptococcosis. BMC Infect Dis [Internet] 2012 [citado 15 Ene 2014]; 12: [aprox. 11 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556098/
13. Sorrell TC, Chen S. Recent advances in management of cryptococcal meningitis: commentary. F1000 Med Rep [Internet]. 2010 [citado 12 Feb 2014]; 2: [aprox. 8 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998879/
14. IllnaitZaragozí MT, Martínez Machín GF, Fernández Andreu CM, Hagen F, Boekhout T, Klaassen CH, et al. Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis. BMC Infect Dis [Internet]. 2010 [citado 12 Feb 2014]; 10: [aprox. 12 p.]. Disponible en: http://www.biomedcentral.com/1471-2334/10/289/
15. Ngamskulrungroj P, Chang Y, Roh J, Kwon-Chung KJ. Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii the two etiologic agents of Cryptococcosis. PLoS ONE [Internet]. 2012 [citado 12 Feb 2014];7(3): [aprox. 12 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313984
16. Castañeda E, Lizarazo J. Protocolo de estudio y manejo de los pacientes con criptococosis. Infectio [Internet]. 2012 [citado 12 Feb 2014]; 16 (35): [aprox. 3 p.]. Disponible en: http://revistainfectio.org/site/portals/0/ojs/index.php/infectio/article /view/583
17. Negroni R, Arechavala A, Maiolo E, Bianchi M, Santiso G, Lehmann E. Problemas clínicos en micología medica: problema número 41. Rev Iberoam Micol [Internet] 2011 [citado 12 Feb 2014]; 28(1): [aprox. 3 p.]. Disponible en: http://www.reviberoammicol.com/2011-28/053055.pdf
18. Sloan D, Dlamini S, Paul N, Dedicoat M. Treatment of acute cryptococcal meningitis in HIV infected adults, with an emphasis on resource-limited settings. Cochrane DatabaseSystRev [Internet] 2008 [citado 12 Feb 2014]; 4 [aprox. 6 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC18843697

Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/