Oxidative stress in diabetes mellitus, role of vitamin E and endogenous antioxidant
Keywords:
Diabetes Mellitus, Vitamin E, Albumins, Uric acid, Bilirubin.Abstract
Introduction: diabetes mellitus is a clinical entity resulting in poor insulin secretion that can be absolute or relative. Hyperglycemia is the biochemical marker of this entity and it is the cause of the characteristic symptoms of its poor control. Hyperglycemia causes neuropathies, nephropathies, microangiopathy and macroangiopathy.Objective: to describe the behavior of vitamin E and endogenous antioxidants in the oxidative stress due to chronic hyperglycemia in diabetes mellitus and the characteristics of these antioxidants.
Conclusions: knowledge updating with respect of vitamins actions and other markers properly used, are crucial for the therapeutic to be followed or as stress markers of this entity, contributing to the instruction of health personnel and to the quality of medical care for the patients diagnosed with a preventable chronic disease.
Downloads
References
1. Chile. MINSAL. Guía Clínica AUGE. Diabetes mellitus tipo 1[Internet]. Chile: MINSAL. 2013; 10. Disponible en: http://web.minsal.cl/portal/url/item/b554e8e580878b63e04001011e017f1e.pdf
2. USA. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care January[Internet]. 2014; 37(Suppl 1): S14-S80. Disponible en: http://care.diabetesjournals.org/content/37/Supplement_1/S14.full
3. Eshaq RS, Wright WS, Harris NR. Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathy. Redox Biol[Internet]. 2014; 2: 661-666. Disponible en: http://www.sciencedirect.com/science/article/pii/S2213231714000597
4. Anu Rahal A, Amit Kumar A, Vivek Singh V, Brijesh Yadav B, Ruchi Tiwari R, et al. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay. BioMed Research International[Internet]. 2014; 2014: 1-19. Disponible en: http://www.hindawi.com/journals/bmri/2014/761264/
5. Gökhan Sadi, Davut Bozan, Huseyin Bekir Yildiz. Redox regulation of antioxidant enzymes: post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver. Molecular and Cellular Biochemistry [Internet]. August 2014, Volume 393, Issue 1-2, pp 111-122. Disponible en: http://link.springer.com/article/10.1007/s11010-014-2051-1/fulltext.html
6. Bouayed J, Bohn T. Exogenous antioxidants—Double-edged swords in cellular redox state. Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev[Internet]. 2010 Jul-Aug; 3(4): 228-237. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952083/
7. Cai W, Ramdas M, Zhu L, Chen X, Striker GE, Vlassara H. Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. PNSA[Internet]. 2012; 109(39). Disponible en: http://www.pnas.org/content/109/39/15888.full.pdf
8. Cruz Hernández J, Licea Puig ME, Hernández García P, Abraham Marcel EA, Yanes Quesada M. Aldosa reductasa y proteína quinasa C en las complicaciones crónicas de la diabetes mellitus. Rev Mex Patol Clin[Internet] 2012; 58(2): 102-107. Disponible en: http://www.medigraphic.com/pdfs/patol/pt-2011/pt112c.pdf
9. Colucci R, Currià M. Diabetes mellitus, hemoglobina glicosilada y stress oxidativo[Internet]. Buenos Aires: Orthomolecular; 2010. Disponible en: http://www.orthomolecularba.com/index.php?option=com_content&view=article&id=72:diabetes-mellitus-hemoglobina-glicosilada-y-stress-oxidativo&catid=38:articulos&Itemid=78
10. Mascio P, Murph ME, Sies H. Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr[Internet] 1991; 53(1): 194-200. Disponible en: http://ajcn.nutrition.org/content/53/1/194S.full.pdf+html
11. Heredia R. D, Fernández C. D, Alfonso R. J, Rodríguez V. E, Santana G. L et al. Sistema antioxidante enzimático e indicadores de daño oxidativo en pacientes diabéticos tipo 2. Rev. chil. endocrinol. Diabetes[Internet] 2014; 7(3): 94-98. Disponible en: http://soched.cl/Revista%20Soched/3_2014/4-Heredia.pdf
12. Gábor C, Francis J, Miller Jr. Oxidative Stress in Cardiovascular Disease. Int J Mol Sci[Internet] 2014 Apr; 15(4): 6002-6008. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013610/
13. López Rodríguez G, Suárez Dieguez T. Albumin and transferrin are antioxidants that prevent lipoperoxidation in vitro. Rev. latinoam. Quím[Internet] 2010; 38(3). Disponible en: http://www.scielo.org.mx/scielo.php?pid=S0370-59432010000300004&script=sci_arttext
14. Díaz Arce D, Cabada Pérez F. Ácido úrico: ¿Antioxidante o pro-oxidante? Su relación con la hipertensión arterial. Rev Panorama Cuba y Salud[Internet] 2010; 5(1): 5-15. Disponible en: http://www.imbiomed.com.mx/1/1/articulos.php?method=showDetail&id_articulo=81813&id_seccion=4731&id_ejemplar=8076&id_revista=308
15. Amar Nagesh K, Pathiputhuru A, Jupalle Nagaiah N, Robby K, Anuj Kumar S. Review of concepts and controversies of uric acid as antioxidant and pro-oxidant - an uncertainty. Archives Medical Review Journal[Internet]. 2015; 24(1): 19-40. Disponible en: http://www.scopemed.org/?mno=162974
16. Itahana Y, Han H, Barbier S, Lei Z, Rozen S, et al. The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. Oncogene[Internet]. 2015; 34(14): 1799-1810. Disponible en: http://www.nature.com/onc/journal/v34/n14/full/onc2014119a.html
17. Cumming KT, Raastad T, Holden G, Bastani NE, et al. Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training. Physiological Reports[Internet]. 7 October 2014; 2(10). Disponible en: http://physreports.physiology.org/content/2/10/e12142.most-read
18. Ogbera AO, Ezeobi E, Unachukwu C, Oshinaike O. Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose. Indian J Endocr Metab[Internet]. 2014; 18(6): 846-9. Disponible en: http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=6;spage=846;epage=849;aulast=Ogbera
19. Bjelakovic G, Nikolova D, Gluud C. Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm? PLoS One[Internet]. 2013; 8(9). Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765487/
20. Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and all-cause mortality: A meta-analysis. Curr Aging Sci. Jul 2011; 4(2): 158-170.
21. Mathew MC, Ervin AM, Tao J, Davis RM. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. Cochrane Database Syst Rev. 2012 Jun 13; 6. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/22696344
22. Rosas Guzmán J, Calles J. Consenso de Prediabetes[Internet]. Argentina: Asociación Latinoamericana de Diabetes (ALAD); 2010. Disponible en: http://www.alad-latinoamerica.org/DOCConsenso/PREDIABETES.pdf
23. Maghzal GJ, Leck MC, Collinson E, Li C, Stocker R. Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase. The journal of biological chemistry[Internet]. 2009; 284(43): 29251-29259. Disponible en: http://www.jbc.org/content/284/43/29251.full.pdf+html
24. Ogbera AO, Ezeobi E, Unachukwu C, Oshinaike O. Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose. Indian J Endocr Metab[Internet]. 2014; 18(6): 846-9. Disponible en: http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=6;spage=846;epage=849;aulast=Ogbera
25. Fabbrini E, Serafini M, Baric IC, Hazen SL, Klein S. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes March[Internet]. 2014; 63(3): 976-981. Disponible en: http://diabetes.diabetesjournals.org/content/63/3/976.full
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/