The interaction of genome and environment with hypertension

Authors

  • Lourdes María Moreno Plasencia Centro Provincial de Genética Médica, Pinar del Río.
  • Roberto Lardoeyt Ferrer Centro Provincial de Genética Médica, Pinar del Río.
  • Maria Beatriz Iglesias Rojas Centro Provincial de Genética Médica, Pinar del Río.
  • Jorge Padilla Preval Centro Provincial de Genética Médica, Pinar del Río.

Keywords:

Hypertension, Gen-environment interaction, Genetics.

Abstract

Introduction: hypertension has a multi-factorial origin in which genetic and environmental factors play an important role, and it is one of the most important health care problems in contemporary medicine. In Cuba the study to find out the interaction of genetic predisposition along with the environmental factors is a challenge.
Objective: to evaluate the interaction of a predisposing genome with adverse environmental factors in the development of this disease.
Material and methods: a case-control study was designed, taking the population of the 19 de abril Polyclinic, in Plaza de la Revolución municipality between the years 2012 and 2014. The sample was comprised of 80 cases and 160 controls, obtained by simple random sampling, environmental factors and genetic risks were assessed, as well as the parental origin for genetic predisposition.
Results: it was found that pathological alcohol consumption, low physical activity; overweight, sugar-rich and low-vegetable diets increase the risk of developing hypertension. Maternal origin of the disease predominated. The interaction of a predisposing genome given by first-degree family history and environmental factors such as obesity increase the probability of developing hypertension. C
Conclusions: adverse environmental factors tend to modulate the genetic predisposition of a predisposing genome for the development of the disease.

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Author Biographies

Lourdes María Moreno Plasencia, Centro Provincial de Genética Médica, Pinar del Río.

Especialista de Primer Grado en Medicina General Integral. Especialista de Primer Grado en Genética Clínica. Máster en Asesoramiento Genético  Instructora.

Roberto Lardoeyt Ferrer, Centro Provincial de Genética Médica, Pinar del Río.

Doctor en Ciencias Médicas. Especialista de Primer y Segundo Grado en Genética Clínica.  Profesor Titular.

Maria Beatriz Iglesias Rojas, Centro Provincial de Genética Médica, Pinar del Río.

Especialista de Primer Grado en Medicina General Integral. Máster en Asesoramiento Genético. Instructora.

Jorge Padilla Preval, Centro Provincial de Genética Médica, Pinar del Río.

Especialista de Primer Grado en Medicina General Integral. Especialista de Primer Grado en Genética Clínica.

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Published

2015-10-28

How to Cite

1.
Moreno Plasencia LM, Lardoeyt Ferrer R, Iglesias Rojas MB, Padilla Preval J. The interaction of genome and environment with hypertension. Rev Ciencias Médicas [Internet]. 2015 Oct. 28 [cited 2025 Aug. 29];19(5):853-67. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/2258

Issue

Vol. 19 No. 5 (2015)

Section

ORIGINAL ARTICLES

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