Whipple's disease, a rare cause of diarrhea
Keywords:
WHIPPLE’S DISEASE, MALABSORPTION, TROPHERYMA, INTESTINAL LIPODYSTROPHY.Abstract
Introduction: Whipple's disease is a very rare infectious, multisystemic condition that affects the gastrointestinal tract and especially the small intestine.
Case report: a 53-year-old white female patient presented to the gastroenterology clinic at Abel Santamaría Cuadrado General Teaching Hospital, referred from her health area, for presenting a chronic diarrheal syndrome without extra-intestinal manifestations, making the diagnosis difficult, that along with the histopathological findings, allowed reaching to the diagnosis.
Conclusion: Whipple's disease is a chronic infection caused by a bacterium of the genus Actninomyces, Tropheryma whippelii, which is very difficult to cultivate and the diagnosis of certainty is currently reached by the histopathological study of serial biopsies of the digestive tract. Antibiotic therapy for a long time is the treatment.
Downloads
References
1. Hano García OM. Enfermedad de Whipple. En: Paniagua Esteves ME, Piñol Jiménez FN. Enfermedad de Whipple. Gastroenterología y hepatología clínica. La Habana: Editorial Ciencias Médicas; 2015. p. 1054-60.
2. Fenollar F, Lagier JC, Raoult D. Tropheryma whipplei and Whipple´s disease. Journal of Infection [Internet]. 2014 [citado 2014 may 28]; 69(2):[Aprox.9p].Disponible en:
https://www.ncbi.nlm.nih.gov/pubmed/24877762
3. Maiwald M, Von Herbay A, Relman DA. Whipple disease. In: Sleisenger and Fordtran’s Gastrointestinal and Liver diseases, Small and large intestine. 10th ed. Philadelphia: Elsevier Saunders; 2016. p. 1886-95.
4. Marth T, Schneider T. Enfermedad de Whipple. Enfermedades infecciosas. Principios y práctica [Internet]. 2016 Jan [citado 24 Feb 2017]; 1:[Aporx 6p]. Disponible en : http://www.studentconsult.es/bookportal/mandell-douglas-bennett/bennett/obra/9788490229170/500/6749.html .
5. West SG. Systemic diseases in which arthritis is a feature. In: Goldman L, Schafer AI. Goldman's Cecil Medicine. 25th ed. Philadelphia: Elsevier Saunders; 2016. p. 275
6. Thomas M, Moos V. Tropheryma whipplei infection and Whipple's disease. The Lancet Infectious Diseases [Internet]. 2016 March [citado 24 Feb 2017]; 16(3): [Aprox.9p].Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/
7. Torres Gutiérrez IP. Enfermedad de Whipple. Revista Médica de Costa Rica y Centroamérica LXXI [Internet]. 2015 [citado 2017 feb 24]; 72(617):[Aprox.2p]. Disponible en: https://www.new.medigraphic.com/cgibin/resumen.cgi?DIDARTICULO=67200.
8. Casals Seoane F, Gisbert JP. Enfermedad de Whipple. Medicine Programa de Formación Médica Continuada [Internet]. 2016 March [citado 2017 feb 24]; 12(5):[Aprox.6p]. Disponible en : http://www.sciencedirect.com/science/article/pii/S0304541216000603

Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/