Etiopathogenesis of non-variceal upper gastrointestinal bleeding, inflammatory response and Helicobacter pylori
Keywords:
HEMORRHAGE, DIGESTIVE SYSTEM DISEASES /complications, HELICOBACTER PYLORI.Abstract
Introduction: the infection triggered by Helicobacter pylori occurs worldwide, although it is more frequent in developing countries and in communities living in poor socioeconomic conditions, where there is overcrowding or migration of regions of high prevalence. The infection occurs mainly during childhood and increases with age.
Method: a literature review on the theme was completed where the mechanisms that trigger the inflammatory response are explicitly explained once the bacteria colonizes the stomach, which includes two stages: the first characterized by the onset and penetration of the microorganism into the gastric mucus, where it colonizes and multiplies and the second stage characterized by an amplification of this inflammatory response.
Development: knowledge of these etiopathogenic mechanisms not only helps the suppression of the bacteria, but also contributes to the regulation of the neuroimmune system before, during and after tissue damage, to achieve adequate tissue regeneration, improve the functional capacity of the bleeding organ and prevent the torpid evolution of the disease.
Conclusions: it facilitates clinicians, gastroenterologists, surgeons and physicians in general, to find the appropriate therapy to eradicate the bacteria, and direct the actions towards the search for treatments capable of regulating the neuroimmune system before, during and after tissue damage to achieve an adequate regeneration of tissue, improve the functional capacity of the bleeding organ and prevent the torpid evolution of the disease.
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