Validation of a questionnaire on the interaction of genetic and environmental factors in the development of bronchial asthma
Keywords:
ASMA BRONQUIAL, EPIGÉNESIS GENÉTICA, MÉTODO DELPHI, VALIDACIÓN.Abstract
Introduction: bronchial asthma is the classic disease among allergic conditions, and has great impact on health worldwide. It is a complex disease both genetically and phenotypically, and genetic-environmental interactions make it even more complex.
Objective: to validate a questionnaire for the study of the involvement of genetic factors and their interaction with environmental factors in the onset of immune disorders due to bronchial asthma.
Method: the study was developed in the Department of Immunology at Pepe Portilla Provincial Pediatric Teaching Hospital in Pinar del Río province. The coordinating group of the technique to be carried out was selected and comprised three professionals responsible for the proposed research. The Delphi Methodology was used, completing its four phases: definition of the topic, selection of experts, implementation of consultation rounds and assessment of results. To determine the agreement or similarities of the responses of the evaluators respectively, the Kendall and Friedman concordance coefficient was calculated.
Results: twenty-one (21) experts with high levels of competence were selected according to the calculation of the coefficients of knowledge and argumentation. In the third version of the questionnaire, there was similarity in the responses of the experts in favor of the higher category of Very Essential, as well as agreement in the level of response of the experts.
Conclusions: the designed questionnaire reaches optimal levels of content validity and feasibility to determine the contribution of genetic factors and their interaction with environmental factors on the onset of immune disorders due to bronchial asthma.
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References
1. Rich RRFA. Clinical Immunology: Principles and Practice. Fifth edit. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder Jr., Anthony J. Frew CM, editor. Elsevier; 2019. 2019 p.
2. Pérez TC. PRECISION MEDICINE AND THE ALLERGIC PATIENT. 2018;135(01):28–32.
3. Bonser LR, Erle DJ. The airway epithelium in asthma. En: Advances in Immunology [Internet]. 1st ed. Vol. 142. Elsevier Inc.; 2019. [citado el 20 de mayo 2020]; 1–34. Available from: http://dx.doi.org/10.1016/bs.ai.2019.05.001
4. Rodrígueza JAC, J.Krause B, Uauya R, Casanello P. Epigenética en enfermedades alérgicas y asma. Rev Chil Ped [Internet]. 2016 [citado el 20 de mayo 2020]; 87(2): [aprox. 7p.]. Available from: https://doi.org/10.1016/j.rchipe.2016.02.006
5. GINA. Global Strategy for Asthma Management and Prevention [Internet]. 2019 [citado el 20 de mayo 2020]. Available from: https://ginasthma.org/reports/2019-gina-report-global-strategy-for-asthma-management-and-prevention/
6. Thibeault A-AH, Laprise C. Firmas de metilación de ADN específicas de células en el asma. Genes (Basel) [Internet]. 2019 [citado el 20 de mayo 2020]; 10(11). Available from: https://doi.org/10.3390/genes10110932
7. Lorena Orozco, Silvia Jiménez-Morales YS. La medicina y la genómica: una nueva síntesis. Primera ed. Laura Vargas-Parada JPL, editor. México: Fondo de Cultura Económica, Fundación mexicana para la salud, Instituto Nacional de Medicina Genómica; 2010. 197–2012 p.
8. Caraballo L. El impacto de la genómica en las enfermedades alérgicas The impact of genomic on alergic diseases. ACTA MED COLOMB [Internet]. 2004 [citado el 20 de mayo 2020]; 29(4): [aprox. 3p.]. Disponible en: http://www.actamedicacolombiana.com/anexo/articulos/03-2004-09.pdf
9. MINSAP. Anuario estadístico [Internet]. 47th ed. Ministerio de Salud Pública. Cuba, editor. Dirección de Registros Médicos y Estadísticas de Salud; 2019. [citado el 20 de mayo 2020]. Available from: https://salud.msp.gob.cu
10. McKusick VA, Hamosh A. SUSCEPTIBILITY TO ASTHMA. OMIM Entry [Internet]. 2010 [citado el 20 de mayo 2020]; (600807). Disponible en: https://www.omim.org/entry/600807
11. Guio H. Hacia la medicina personalizada: implicancias de las ciencias básicas y las “ómicas” en la práctica clínica. Rev Peru Med Exp Salud Publica. [Internet]. 2015 [citado el 20 de mayo 2020]; 32(4): [aprox. 3p.]. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342015000400001
12. Lambrecht BN, Hammad H, Fahy J V. 25 Review The Cytokines of Asthma. Immunity [Internet]. 2019 [citado el 20 de mayo 2020]; 50(4): [aprox. 15p.]. Available from: https://doi.org/10.1016/j.immuni.2019.03.018
13. Wu. W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, et al. Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. Am J Respir Crit Care Med [Internet]. 2019 [citado el 20 de mayo 2020]; 199(11): [aprox. 10p.]. Available from: https://doi.org/10.1164/rccm.201808-1543OC
14. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-scroggins ME, Peters MC. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. ResearchGate [Internet]. 2016 [citado el 20 de mayo 2020]; 113(31): [aprox. 15p.]. Available from: https://www.researchgate.net/publication/305419006
15. Fonseca MR-ÁYMT. El método Delphi. Revista d’Innovació i Recerca en Educació [Internet]. 2016 [citado el 20 de mayo 2020]; 9(1): [aprox. 15p.]. Disponible en: http://diposit.ub.edu/dspace/bitstream/2445/110707/1/654735.pdf
16. Lugo NT, Ferrer RL. Validation of a questionnaire about risk factors for congenital defects Introducción. Rev Cuba Investig Biomédicas [Internet]. 2019 [citado el 20 de mayo 2020]; 38(4): [aprox. 18p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002019000400011&lng=en&nrm=iso&tlng=en
17. Gil B, Pascual-Ezama D. The delphi method as a technique to study validity of content. An Psicol [Internet]. 2012 [citado el 20 de mayo 2020]; 28(3): [aprox. 9p.]. Disponible en: https://revistas.um.es/analesps/article/view/analesps.28.3.156211
18. Carvajal A, Centeno C, Watson R, Martínez M, Rubiales AS. [How is an instrument for measuring health to be validated?]. An Sist Sanit Navar [Internet]. 2011 [citado el 20 de mayo 2020]; 34(1): [aprox. 9p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21532647
19. George Reyes CE, Trujillo Liñan L. Aplicación del Método Delphi Modificado para la Validación de un Cuestionario de Incorporación de las TIC en la Práctica Docente. Rev Iberoam Evaluación Educ [Internet]. 2018 [citado el 20 de mayo 2020]; 11(1): [aprox. 20p.]. Disponible en: https://revistas.uam.es/index.php/riee/article/view/9265
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