Coexistence of facial dysmorphia and congenital malformations in human fetuses

Authors

Keywords:

HEART DISEASES, CONGENITAL ABNORMALITIES, FETUS, MICROGNATHISM, RETROGNATHIA.

Abstract

Introduction: facial dysmorphia is a topic approached from multiple angles. The coexistence of these and other disorders of the human body can be explained by the processes that occur during the development of the embryo.

Objective: to determine the relationship between facial dysmorphia and congenital malformations present in the system of organs in human fetuses.

Methods: an analytical, cross-sectional, observational research was carried out on 42 human fetuses resulting from pregnancy interruptions. During the autopsy, facial structures were measured. Facial profile, symmetry, existence of facial hypoplasias and congenital malformations in different system of organs were considered.

Results: 66,7 % of male fetuses were observed, average maternal age was 29,3 ± 7,5 years. Dysmorphia of the facial profile (73,8 %), the frontal region (57,1 %) and the jaw (54,7 %) were more frequent. Only cardiovascular malformations showed a positive, significant correlation with signs of facial dysmorphia (p=0,006; R=0,414).

Conclusions: facial dysmorphia in human fetuses was related to malformations of the cardiovascular system, which could be useful in the early diagnosis of congenital heart defects.

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Author Biographies

Isvel Zaldivar Garit, Universidad de Ciencias Médicas de Pinar del Río

Especialista de Primer Grado en Medicina General Integral y Embriología Clínica. Profesor Auxiliar.

Presidente del Capítulo provincial de la Sociedad Cubana de Ciencias Básicas Biomédicas.

Elisa Maritza Linares Guerra, Universidad de Pinar del Río “Hermanos Sainz Montes de Oca”.

Doctora en Ciencias Médicas. Licenciada en Bioquímica. Profesora Titular.

Deysi Licourt Otero, Universidad de Ciencias Médicas de Pinar del Río. Centro Provincial de Genética Médica.

Especialista de segundo grado en Genética Clínica. Profesor auxiliar.

Rafaela Díaz del Pino, Universidad de Ciencias Médicas de Pinar del Río

Máster en educación médica. Especialista de segundo grado en embriología. Profesora auxiliar.

Mileidys León García, Universidad de Ciencias Médicas de Pinar del Río

Especialista de primer grado en Medicina General Integral y Fisiología Normal y Patológica. Profesora Auxiliar

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Published

2021-02-22

How to Cite

1.
Zaldivar Garit I, Linares Guerra EM, Licourt Otero D, Díaz del Pino R, León García M. Coexistence of facial dysmorphia and congenital malformations in human fetuses. Rev Ciencias Médicas [Internet]. 2021 Feb. 22 [cited 2025 Aug. 28];25(1):e4618. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/4618

Issue

Vol. 25 No. 1 (2021)

Section

ORIGINAL ARTICLES

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