Human papillomavirus infection and oral squamous cell carcinoma: a systematic review
Keywords:
HUMAN PAPILLOMAVIRUS VIRUSES, MOUTH NEOPLASMS, OROPHARYNGEAL NEOPLASMS, CARCINOMA, SQUAMOUS CELL.Abstract
Introduction: squamous cell carcinoma (SCC) is the most common cancer in the oral cavity, it represents 5 % of all neoplasms and occupies number 12 of all malignant neoplasms, there is a relationship between the cervix, oral cavity and oropharynx.
Objective: to argue the relationship between human papillomavirus (HPV) infection and oral squamous cell carcinomas.
Methods: a systematic literature review was performed, 60 articles indexed in (Pubmed, Scopus, Cochrane Library, Google Scholar and SciELO) were reviewed. Only bibliographic and systematic reviews with less than 10 years of publication, based on human studies, published in English or Spanish and with the text available were included. All those studies that did not meet these parameters were excluded, leaving a total of 16 results.
Development: squamous cell carcinoma represents 90 % of malignant neoplasms of the oral cavity and oropharynx. There are several HPV types among them 201 types that differ due to variations in the L1 DNA sequence. The literature deduces that 17,8 % of all cancers are stimulated by contagious type agents and 12,1 % belong to viruses, this forces to inquire more about HPV as a carcinogenic agent and its contribution in squamous cell carcinoma (SCC) in oral cavity and oropharynx.
Conclusions: the carcinogenic mechanisms used by HPV for cell transformation are through E6 and E7 proteins as responsible for the malignization process.
Downloads
References
1. de la Fuente Hernández J, Muñoz Mújica P, Patrón Bolaños CE, Ramírez Trujillo M de los Á, Rojas Mercado HJ, Acosta Torres LS. Aumento de la incidencia de carcinoma oral de células escamosas. Salud ciencia (Impresa) [Internet]. 2014 [citado 21/11/2022]; 20(6): 636-42. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/lil-796464
2. Contreras W, Venegas B. Virus Papiloma Humano en Cáncer Oral y Orofaríngeo: Revisión de la Literatura. International journal of odontostomatology [Internet]. Diciembre de 2015 [citado 11/11/2022]; 9(3): 427-35. Disponible en: http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0718-381X2015000300012&lng=es&nrm=iso&tlng=es
3. Melo BA de C, Vilar LG, Oliveira NR de, Lima PO de, Pinheiro M de B, Domingueti CP, et al. Human papillomavirus infection and oral squamous cell carcinoma - a systematic review. Braz J Otorhinolaryngol [Internet]. 2021 [citado 13/11/2022]; 87(3): 346-52. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33339760/
4. Ontañón AV, Losa JH, Haro RSL de, Paricio BB, Agüeras SRC, Atín SB, et al. Impacto del virus papiloma humano en pacientes afectos de carcinoma escamoso de cavidad oral y orofaringe. Medicina clínica [Internet]. 2019 [citado 11/10/2022]; 152(5): 174-80. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=6805242
5. Office of the Chief Dental Officer of Canada1. Human papillomavirus and oral health. Can Commun Dis Rep [Internet]. 5 de noviembre de 2020 [citado 11/11/2022]; 46(1112): 380-3. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33447158/
6. Ding Y, Ma L, Shi L, Feng J, Liu W, Zhou Z. Papillary squamous cell carcinoma of the oral mucosa: a clinicopathologic and immunohistochemical study of 12 cases and literature review. Ann Diagn Pathol [Internet]. Febrero de 2013 [citado 13/11/2022]; 17(1): 18-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22672806/
7. Howard A, Agrawal N, Gooi Z. Lip and Oral Cavity Squamous Cell Carcinoma. Hematol Oncol Clin North Am [Internet]. Octubre de 2021 [citado 11/11/2022]; 35(5): 895-911. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34274176/
8. Medina MG, Marinic K, Medina ML, Sorrentino A, Giménez MF, Merino LA. Detección de papilomavirus humano en mucosa oral en hombres con verrugas anogenitales. Memorias del Instituto de Investigaciones en Ciencias de la Salud [Internet]. Agosto de 2021 [citado 10/11/2022]; 19(2): 41-8. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_abstract&pid=S1812-95282021000200041&lng=en&nrm=iso&tlng=es
9. Mendoza WAV, Robles JLM. Virus del Papiloma Humano y su relación con el cáncer orofaríngeo. Revista San Gregorio [Internet]. 31 de diciembre de 2021 [citado 12/11/2022]; (48): 123-48. Disponible en: https://revista.sangregorio.edu.ec/index.php/REVISTASANGREGORIO/article/view/1771
10. Maraboli-Contreras S, Adorno-Farías D, Maturana-Ramírez A, Rojas-Alcayaga G, Fuentes-Alburquenque M, Espinoza-Santander I, et al. Sobrevida de carcinoma oral de células escamosas: reporte de la Universidad de Chile. Revista clínica de periodoncia, implantología y rehabilitación oral [Internet]. Diciembre de 2018 [citado 12/11/2022]; 11(3): 147-51. Disponible en: http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0719-01072018000300147&lng=es&nrm=iso&tlng=es
11. Verano Gómez NC, Escobar Urcuango A, Romero Fernández AJ, Verano Gómez NC, Escobar Urcuango A, Romero Fernández AJ. Conocimientos de los estudiantes de odontología sobre el virus del papiloma humano asociado al cáncer orofaríngeo. Conrado [Internet]. Octubre de 2021 [citado 12/11/2022]; 17(82): 240-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1990-86442021000500240&lng=es&nrm=iso&tlng=es
12. Valdez-Flores AI, Garnica-Núñez C, Urías-Barreras CM, Rafael E, Batiz-Salazar DM. Virus del papiloma humano en carcinoma de células escamosas de cabeza y cuello. Rev Med UAS [Internet]. 2016 [citado 10/11/2022]; 6(3). Disponible en: https://hospital.uas.edu.mx/patologia/Articulos/14.pdf
13. de Abreu PM, Có ACG, Azevedo PL, do Valle IB, de Oliveira KG, Gouvea SA, et al. Frequency of HPV in oral cavity squamous cell carcinoma. BMC Cancer [Internet]. 27 de marzo de 2018 [citado 12/11/2022]; 18(1): 324. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29580212/
14. Boguñá N, Capdevila L, Jané-Salas E. Relationship of human papillomavirus with diseases of the oral cavity. Med Clin (Barc) [Internet]. 16 de agosto de 2019 [citado 10/11/2022]; 153(4): 157-64. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31109717/
15. Johanning Cordero JC. Carcinoma escamoso de cavidad oral y orofaringe asociado a virus del papiloma humano: características epidemiológicas, histopatológicas y la importancia de las pruebas inmunohistoquímicas y moleculares en su diagnóstico [Internet]. Universidad de Costa Rica, San José, Costa Rica; 2020 [citado 30/12/2022]. Disponible en: https://kerwa.ucr.ac.cr/handle/10669/82332
16. Berman TA, Schiller JT. Human papillomavirus in cervical cancer and oropharyngeal cancer: One cause, two diseases. Cáncer [Internet]. 15 de junio de 2017 [citado 12/11/2022]; 123(12): 2219-29. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28346680/
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
