Hepatoblastoma in children

Authors

Keywords:

HEPATOBLASTOMA, CHILDHOOD, LIVER CANCER.

Abstract

Introduction: hepatoblastoma is the most common liver tumor in childhood, its survival currently exceeds 70 %. The main prognostic factor is the clinical stage.

Objective: to describe the clinical-epidemiological factors of childhood hepatoblastoma, the main primary malignant tumor of the liver in children.

Methods: to carry it out, 30 scientific articles on the topic were consulted, obtained from the databases PubMed, Medline, Scielo and Google Scholar, and 27 were used as bibliographies, articles published during the last five years and others predominated due to their relevance.

Development: a hepatoblastoma is a rare tumor that grows from liver cells. It is the most common liver cancer in childhood, occurring during the first 18 months of life (from infants to five years of age), mostly in white, male children born prematurely with low birth weight.

Conclusions: the most important prognostic factor for survival of patients with hepatoblastoma is total surgical resection. Secondly, the presence of metastatic disease at diagnosis, although this factor has been modified by treatment with neoadjuvant chemotherapy. The third factor is histology, where the fetal variety has a better prognosis.

Downloads

Download data is not yet available.

Author Biographies

Boris Bencomo-García, Hospital Pediátrico Provincial Docente Pepe Portilla

Especialista de Primer Grado en Pediatría. Sala de Oncohematología, Hospital Pediátrico Provincial Docente Pepe Portilla.

Jennifer Mirtha Cruz-Pimienta, Hospital Pediátrico Provincial Docente Pepe Portilla

Licenciada en psicología. Master en enfermedades oncohematológicas. Psicóloga infanto-juvenil en en el servicio de oncohematología.

References

1. Valdés Guerrero R, Valdés Blanco M, Rodríguez Venegas EC, Cabrera Nicó A, Fontaine Ortiz JE, Díaz Villalvilla C. Tumores hepáticos en edad pediátrica. Rev Cubana Pediatr [Internet]. 2020 Sep [citado 04/11/2023]; 92(3): e876. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312020000300003&lng=es.

2. Marcano Sanz LE, Endis M, Llanos F, Chimbo J, Abril X, Faican F, et al. Hepatectomía central combinada con ligadura de la vena porta derecha en un niño con hepatoblastoma bilobar: reporte de un caso. Revista Colombiana de Cancerología [Internet]. 2020 [citado 04/12/2023]; 24(4): 195-99. Disponible en: https://www.revistacancercol.org/index.php/cancer/article/view/468.

3. Verdecia Cañizares C. Tumores hepáticos en pediatría. Rev Cubana Pediatr [Internet]. 2020 Sep [citado 04/12/2023]; 92(3): e1188. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312020000300001&lng=es.

4. Hubbard AK, Spector LG, Fortuna G, Marcotte EL, Poynter JN. Trends in International Incidence of Pediatric Cancers in Children Under 5 Years of Age: 1988–2012. JNCI Cancer Spectr [Internet]. 2019 [citado 13/11/2023]; 3(1): pkz007. Disponible en: https://academic.oup.com/jncics/article/3/1/pkz007/5435642?login=true.

5. Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, Meyer RE, Canfield MA, et al. Cancer diagnostic profile in children with structural birth defects: An assessment in 15,000 childhood cancer cases. Cancer [Internet]. 2020 [citado 04/12/2023]; 126(15): 3483–92. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.32982.

6. Heaton TE, Walsh MF. Hepatoblastoma in infants born to parents with familial adenomatous polyposis. In: Guillem J, Friedman G, editors. Management of hereditary colorectal cancer Amultidisciplinary approach [Internet]. Springer; 2020 [citado 04/12/2023]: 123-36. Disponible en: https://link.springer.com/chapter/10.1007/978-3-030-26234-1_7.

7. Cohen MM. Beckwith-Wiedemann syndrome: historical, clinicopathological, and etiopathogenetic perspectives. Pediatr Dev Pathol [Internet]. 2005 [citado 04/12/2023]; 8(3): 287-304. Disponible en: https://doi.org/10.1007/s10024-005-1154-9

8. Cereda A, Carey JC. The trisomy 18 syndrome. Orphanet J Rare Dis [Internet]. 2012 [citado 04/12/2023]; 7: 81. Disponible en: https://link.springer.com/content/pdf/10.1186/1750-1172-7-81.pdf.

9. Ishak KG, Glunz PR. Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report of 47 cases. Cancer [Internet]. 1967 [citado 12/02/2023]; 20(3): 396-422. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/1097-0142(1967)20:3%3C396::AID-CNCR2820200308%3E3.0.CO;2-O.

10. Kiruthiga KG, Ramakrishna B, Saha S, Sen S. Histological and immunohistochemical study of hepatoblastoma: correlation with tumourbehaviour and survival. J Gastrointest Oncol [Internet]. 2018 [citado 12/02/2023]; 9(2): 326-37. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934143/.

11. Vishnoi JR, Sasidhar A, Misra S, Pareek P, Khera S, Kumar S, et al. Hepatoblastoma in a Young Adult: a Rare Case Report and Review of the Literature. J Gastrointest Cancer [Internet]. 2020 [citado 12/02/2023]; 51(1): 319-24. Disponible en: https://link.springer.com/article/10.1007/s12029-019-00256-3.

12. Style CC, Cruz SM, Lau PE, Lee TC, Wesson DE, Olutoye OO. Surgical Outcomes of Patients with Beckwith-Wiedemann Syndrome. J PediatrSurg [Internet]. 2018 [citado 12/11/2023]; 53(5): 1042-5. Disponible en: https://doi.org/10.1016/j. jpedsurg.2018.02.041.

13. Subramanian KS, Chikhale M, Barwad A, Gochhait D, Toi PC, Siddaraju N. Fine-needle aspiration cytology and cell block in diagnosis and subtyping of hepatoblastoma. Diagn Cytopathol [Internet]. 2019 [citado 02/11/2023]; 47(7): 706-10. Disponible en: https://doi.org/10.1002/dc.24167.

14. Yang T, Whitlock RS, Vasudevan SA. Surgical Management of Hepatoblastoma and Recent Advances. Cancers (Basel) [Internet]. 2019 [citado 02/11/2023]; 11(12): 1944. Disponible en: https://doi.org/10.3390/cancers11121944.

15. Lake CM, Tiao GM, Bondoc AJ. Surgical management of locally-advanced and metastatic hepatoblastoma. Semin Pediatr Surg [Internet]. 2019 [citado 02/11/2023]; 28(6): 150856. Disponible en: https://doi.org/10.1016/j.sempedsurg.2019.1

16. Souzaki R, Kawakubo N, Matsuura T, Yoshimaru K, Koga Y, Takemoto J, et al. Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients. Pediatr SurgInt [Internet]. 2019 [citado 02/11/2023]; 35: 551-7. Disponible en: https://doi.org/10.1007/s00383-019-04458-5

17. Angelico R, Grimaldi C, Gazia C, Saffioti MC, Manzia TM. How Do Synchronous Lung Metastases Influence the Surgical Management of Children with Hepatoblastoma? An Update and Systematic Review of the Literature. Cancers (Basel) [Internet]. 2019 [citado 02/11/2023]; 11(11): 1693. Disponible en: https://www.mdpi.com/2072-6694/11/11/1693/pdf.

18. de Freitas Paganoti G, Tannuri ACA, Dantas Marques AC, Torres RR, Mendes Gibelli NE, Tannuri U. Extensive Hepatectomy as an Alternative to Liver Transplant in Advanced Hepatoblastoma: A New Protocol Used in a Pediatric Liver Transplantation Center. Transplant Proc [Internet]. 2019 [citado 02/11/2023]; 51(5): 1605-10. Disponible en: https://doi.org/10.1016/j.transproceed.2019.03.004

19. Fagenson AM, Gleeson EM, Nabi F, Lau KN, Pitt HA. When does a Pringle Maneuver cause harm? HPB (Oxford) [Internet]. 2021 [citado 02/11/2023]; 23(4): 587-594. Disponible en: https://doi.org/10.1016/j.hpb.2020.07.014

20. Yamada Y, Ohno M, Fujino A, Kanamori Y, Irie R, Yoshioka T, et al. Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green. Cancers (Basel) [Internet]. 2019 [citado 02/11/2023]; 11(8). Disponible en: https://www.mdpi.com/2072-6694/11/8/1215/pdf.

21. Katzenstein HM, Langham MR, Malogolowkin MH, Krailo MD, Towbin AJ, McCarville MB, et al. Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children’s Oncology Group, multicentre, phase 3 trial. Lancet Onco [Internet]. 2019 [citado 02/11/2023]; 20(5): 719–27. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499702/.

22. Feng J, He Y, Wei L, Chen D, Yang H, Tan R, et al. Assessment of Survival of Pediatric Patients With Hepatoblastoma Who Received Chemotherapy Following Liver Transplant or Liver Resection. JAMA Netw Open [Internet]. 2019 [citado 02/11/2023]; 2(10): e1912676. Disponible en: https://doi.org/10.1001/jamanetworkopen.2019.12676

23. Otte JB, Pritchard J, Aronson DC, Brown J, Czauderna P, Maibach R, et al. International Society of Pediatric O. Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer [Internet]. 2004 [citado 02/11/2023]; 42(1): 74-83. Disponible en: https://doi.org/10.1002/pbc.10376

24. Kachanov DY, Aliev TZ, Moiseenko RA, Roschin VY, Metelin AV, Uskova NG, et al. Hepatoblastoma relapses with a normal level of alpha-fetoprotein: report of two cases. PediatricHematology/Oncology and Immunopathology [Internet]. 2019 [citado 02/11/2023]; 18(4): 58-65. Disponible en: https://doi.org/10.24287/1726-1708-2019-18-4-58-65

25. Semeraro M, Branchereau S, Maibach R, Zsiros J, Casanova M, Brock P, et al. Relapses in hepatoblastoma patients: clinical characteristics and outcome--experience of the International Childhood Liver Tumour Strategy Group (SIOPEL). Eur J Cancer [Internet]. 2019 [citado 02/11/2023]; 49(4): 915–22. Disponible en: https://doi.org/10.1016/j. ejca.2012.10.003

26. Matsunaga T, Sasaki F, Ohira M, Hashizume K, Hayashi A, Hayashi Y, et al. Japanese Study Group for Pediatric Liver T. Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma. Pediatr Surg Int [Internet]. 2003 [citado 02/11/2023]; 19(3): 142-6. Disponible en: https://doi.org/10.1007/s00383-002-0906-0

27. Yamada Y, Hoshino K, Mori T, Kawaida M, Abe K, Takahashi N, et al. Metastasectomy of Hepatoblastoma Utilizing a Novel Overlay Fluorescence Imaging System. J Laparoendosc Adv Surg Tech A [Internet]. 2018 [citado 02/11/2023]; 28(9): 1152-5. Disponible en: https://doi.org/10.1089/lap.2017.0735

Published

2024-02-26

How to Cite

1.
Bencomo-García B, Cruz-Pimienta JM, Macias-Casal CN. Hepatoblastoma in children. Rev Ciencias Médicas [Internet]. 2024 Feb. 26 [cited 2025 Sep. 17];28(1):e6276. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/6276

Issue

Section

REVIEW ARTICLES