Evaluation of the treatment of deep dermal burns with mesenchymal stem cells
Keywords:
BURNS, STEM CELL, ADIPOSE TISSUE, SURGERY, PLASTIC.Abstract
Introduction: stem cells derived from adipose tissue have great therapeutic potential because they are inexpensive and invasive to obtain and their number is greater than that of bone marrow progenitors.
Objective: to characterize the results of the use of mesenchymal stem cells from autologous fat tissue in dermal burns.
Methods: quasi-experimental, exploratory, controlled, open, single-center, longitudinal and prospective study. The universe and the sample coincide from a non-probabilistic intentional sampling, all patients who attended the outpatient clinic of Plastic Surgery and Caumatology of the Hospital Clínico-Quirúrgico Docente “Dr. Miguel Enríquez” with deep dermal burns of up to 3% of body surface were taken into account.
Results: the ages most prone to suffer burns, in this sample, are those between 19 and 34 years old (almost 65 % of those treated). By sex, men between 25 and 29 years of age accounted for almost one out of every five burn victims. The healing time of the patients treated with mesenchymal stem cells was less than seven days (more than 80 % of the patients) and only one patient took more than 14 days to heal. The main complication presented was bleeding, with almost a third of the cases treated.
Conclusions: multiple resources have been allocated by health systems to accelerate the epithelialization process and/or seek skin coverage, and today there is still no real and efficient mechanism to solve this problem.
Downloads
References
1. Kasielska Trojan A, Zieliński T, Antoszewski B. Autologous fat transfer for facial recontouring in Parry-Romberg syndrome. J Cosmet Dermatol. [Internet] 2020 [citado 05/12/2023]; 19(3):585-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31301095/
2. Drochioi CI, Sulea D, Timofte D, Mocanu V, Popescu E, Costan VV. Autologous fat grafting for craniofacial reconstruction in oncologic patients. Medicina (Kaunas). [Internet] 2019 [citado 05/12/2023]; 55(10):655. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843458/
3. Schultz KP, Raghuram A, Davis MJ, Abu Ghname A, Chamata E, Rohrich RJ. Fat grafting for facial rejuvenation. Semin Plast Surg. [Internet] 2020 [citado 05/12/2023]; 34(1):30-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32071577/
4. Zheng H, Yu Z, Deng M, Cai Y, Wang X, Xu Y, et al. Fat extract improves fat graft survival via proangiogenic, anti-apoptotic and pro-proliferative activities. Stem Cell Res Ther. [Internet] 2019[citado 05/12/2023]; 10(1):174. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31196213/
5. Cornejo P, Alcolea JM, Trelles MA. Perspectives on the use of soft tissue fillers from our experience. Part I. Cir.Plást. Iberolatinoam. [Internet] 2011[citado 05/12/2023]; 37(4):393-401. Disponible en: http://scielo.isciii.es/pdf/cpil/v37n4/original13.pdf
6. Packer JD, Chang WT, Dragoo JL. The Use of vibrational energy to isolate adipose-derived stem cells. Plast Reconstr Surg Glob Open. [Internet] 2018[citado 05/12/2023]; 6(1):e1620. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811289/
7. Girard AC, Mirbeau S, Atlan M, Festy F, Roche R, Hoareau L. De la biología al injerto de tejido adiposo: cómo mejorar el lipoinjerto. Cir. Plást. Iberolatinoam. [Internet] 2013 [citado 05/12/2023]; 39(1):33-8. Disponible en: https://dx.doi.org/10.4321/S0376- 78922013000500010
8. Tamayo Carbón AM, Bencosme Escarramán YY, Medina Robainas RE. Supervivencia del injerto graso. factores pronósticos. Rev Cient Cienc Med. [Internet] 2020 Dic [citado 15/03/2024]; 23(2):231-9. Disponible en: https://rccm-umss.com/index.php/revistacientificacienciamedica/article/view/275
9. Clauser L. Autologous facial fat transfer: Soft tissue augmentation and regnenerative Therapy. J Craniofac Surg. [Internet] 2020 [citado 05/12/2023]; 31(7):1879-82. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32796302/
10.Billings E Jr, May JW Jr. Historical review and present status of free fat graft autotransplantation in plastic and reconstructive surgery. Plast Reconstr Surg. [Internet] 1989 [citado 05/12/2023]; 83(2):368-81. Disponible en: https://pubmed.ncbi.nlm.nih.gov/2643129/
11. Neuber G. Über die Wiederanheilung vollständig vom Körper getrennter, die ganze Fettschicht enthaltender Hautstücke. In: Zbl f Chirurgie. Berlin. [Internet] 1993 [citado 05/12/2023]; 30:16-7. Disponible en: https://www.scirp.org/reference/referencespapers?referenceid=1606805
12.Lexer E. Die freien Transplantationen. Zwei Teile. Mit (zus.) 821 teils farbigen Textabbildungen; 1919[citado 05/12/2023]. Disponible en: https://www.abebooks.com/servlet/BookDetailsPL?bi=22817686175
13.Meruane M. Lipoinyección: Conceptos básicos Y aplicación clínica. Rev. Med. Clin. Condes. [Internet] 2016 [citado 05/12/2023]; 27(1):93-106. Disponible en: https://www.researchgate.net/publication/292949739_LIPOINYECCION_CONCEPTOS_BASICOS_Y_APLICACION_CLINICA
14.Peer LA. Transplantation of tissues. Baltimore: Williams & Wilkins. [Internet] 1955 [citado 05/12/2023]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK500177/
15.PierreFournier F. Microlipoextraction et microlipoinjection. Rev Cir Esthét Langue. [Internet] 1985; [citado 05/12/2023]; 10:36-40. Disponible en: https://www.scirp.org/reference/referencespapers?referenceid=1812813
16.Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthetic Plast Surg. [Internet] 1995 [citado 05/12/2023]; 19(5):421-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/8526158/
17.Bertossi D, Zancanaro C, Trevisiol L, Albanese M, Ferrari F, Nocini PF. Lipofilling of the lips. Arch Facial Plast Surg [Internet] 2003 [citado 05/12/2023]; 5(5):392–8. Disponible en: http://jamanetwork.com/journals/jamafacialplasticsurgery/fullarticle/480071.
18.Chajchir A, Chajchir G. Injerto graso con factores de crecimiento y células madre. Cir.Plást.Iberolatinoam [Internet] 2013 [citado 12/05/2023]; 39(1):S8-S10. Disponible en: https://scielo.isciii.es/pdf/cpil/v39s1/original2.pdf
19.Rigotti G, Marchi A, Galiè M, Baroni G, Benati D, Krampera M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. [Internet] 2007 [citado 05/12/2023]; 119(5):1409-22. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17415234/
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
