Regarding a case of acute renal failure induced by nonsteroidal anti-inflammatory drugs
Keywords:
ANTIINFLAMATORIOS NO ESTEROIDEOS; EFECTOS COLATERALES Y REACCIONES ADVERSAS RELACIONADOS CON MEDICAMENTOS; INSUFICIENCIA RENAL; LESIÓN RENAL AGUDA., ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; RENAL INSUFFICIENCY; ACUTE KIDNEY INJURY., ANTI-INFLAMATÓRIOS NÃO ESTEROIDES; EFEITOS COLATERAIS E REAÇÕES ADVERSAS RELACIONADOS A MEDICAMENTOS; INSUFICIÊNCIA RENAL; INJÚRIA RENAL AGUDA.Abstract
Introduction: acute kidney injury induced by nonsteroidal anti-inflammatory drugs is a frequent and potentially reversible complication when detected in a timely manner.
Objective: to describe the clinical presentation and evolution of a patient with acute kidney injury secondary to the use of anti-inflammatory drugs.
Case presentation: a 20-year-old male patient, originally from pichincha and residing in ambato, with a history of knee surgery and consumption of multiple analgesics and anti-inflammatory drugs, including Celecoxib and Ketorolac, is presented. He was admitted with abdominal pain, recurrent vomiting, and oliguria. Laboratory tests revealed elevated creatinine levels (3,25 mg/dl), increased urea, and electrolyte disturbances. Abdominal ultrasound showed findings suggestive of acute kidney injury. The medications were discontinued, and conservative management with hydration and fluid-electrolyte control was initiated. Clinical evolution was favorable, with progressive normalization of creatinine levels and recovery of renal function in the following weeks.
Conclusions: this case highlights the importance of early diagnosis and prompt discontinuation of anti-inflammatory drugs in patients with signs of kidney injury. It underscores the need for responsible prescribing and appropriate monitoring in at-risk patients, particularly those with preexisting comorbidities. Conservative management can reverse renal dysfunction and prevent progression to irreversible renal failure.
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