Impact of teeth whitening on dental sensitivity in patients with diabetes

Authors

Keywords:

BLANQUEAMIENTO DE DIENTES; DIABETES MELLITUS; ODONTOLOGÍA; SENSIBILIDAD DE LA DENTINA., TOOTH BLEACHING; DIABETES MELLITUS; DENTISTRY; DENTIN SENSITIVITY., CLAREAMENTO DENTAL; DIABETES MELLITUS; ODONTOLOGÍA; SENSIBILIDADE DA DENTINA.

Abstract

Introduction: diabetes alters the body’s response to dental procedures, increasing susceptibility to complications such as tooth sensitivity after bleaching.

Objective: to analyze how dental bleaching influences tooth sensitivity in young patients with diabetes.

Methods: a bibliographic search was conducted across different databases, for which a search algorithm was developed, taking into account various descriptors related to the topic. After identifying the available sources, those meeting the inclusion and exclusion criteria were selected, and the literature was analyzed to address the subject matter.

Development: findings show that sustained hyperglycemia affects pulp homeostasis and increases predisposition to inflammation and caries. Dental bleaching, by exposing dentin and opening dentinal tubules, intensifies sensitivity in diabetic patients. A higher incidence of postoperative pain, xerostomia, and risk of infections has been reported. Comparative studies indicate that up to 40 % of diabetic patients experience sensitivity after the procedure, compared to 20 % of non-diabetic patients. The literature highlights the need for adapted protocols, including the use of desensitizing agents, strict glycemic control, and specialized dental follow-up.

Conclusions: dental bleaching in patients with diabetes may exacerbate tooth sensitivity and lead to additional complications. An interdisciplinary approach is recommended, combining metabolic control, rigorous oral hygiene, and safe dental techniques to ensure aesthetic results without compromising pulp health.

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References

1. Epple M, Meyer F, Enax J. A Critical Review of Modern Concepts for Teeth Whitening. Dent J[Internet]. 2019[citado 05/07/2024]; 7(3): 79. Disponible en: https://doi.org/10.3390/dj7030079

2. Pascolutti M, De Oliveira D. A Radical-Free Approach to Teeth Whitening. Dent J[Internet]. 2021[citado 05/07/2024]; 9(12):148. Disponible en:https://doi.org/10.3390/dj9120148

3. Agrafioti P, Morin‐Baxter J, Tanagala KKK, Dubey S, Sims P, Lalla E, et al. Decoding the role of macrophages in periodontitis and type 2 diabetes using single‐cell RNA‐sequencing. The FASEB Journal [Internet]. 2022 feb[citado 05/07/2024]; 36(2): e22136 . Disponible en: https://doi.org/10.1096/fj.202101198R

4. Catanzaro O, Dziubecki D, Lauria LC, Ceron CM, Rodriguez RR. Diabetes and its effects on dental pulp. J Oral Sci[Internet]. 2006[citado 05/07/2024]; 48(4): 195-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17220616/

5. Genco RJ, Borgnakke WS. Diabetes as a potential risk for periodontitis: association studies. Periodontology 2000[Internet]. 2020 junio[citado 05/07/2024]; 83(1):40-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32385881/

6. Ko KI, Sculean A, Graves DT. Diabetic wound healing in soft and hard oral tissues. Transl Res[Internet]. 2021[citado 05/07/2024]; 236: 72-86. Disponible en:https://pubmed.ncbi.nlm.nih.gov/33992825/

7. Baeza M, Morales A, Cisterna C, Cavalla F, Jara G, Isamitt Y, et al. Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis. J Appl Oral Sci[Internet]. 2020[citado 05/07/2024]; 28: e20190248. Disponible en:https://doi.org/10.1590/1678-7757-2019-0248

8. Byun JS, Lee HY, Tian J, Moon JS, Choi J, Lee SH, et al. Effect of Salivary Exosomal miR-25- 3p on Periodontitis With Insulin Resistance. Front Immunol[Internet]. 2022[citado 05/07/2024]; 12: 775046. Disponible en: https://doi.org/10.3389/fimmu.2021.775046

9. Koc Vural U, Atalay C, Miletić I, Gurgan S. Effects of Different Whitening Agents on the Color and Translucency of Different Resin Composites. Acta Stomatol Croat[Internet]. 2023[citado 05/07/2024]; 57(4): 316-28. Disponible en: https://doi.org/10.15644/asc57/4/3

10. Zhang H, Zhang Y, Chen X, Li J, Zhang Z, Yu H. Effects of statins on cytokines levels in gingival crevicular fluid and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus PLoS ONE [Internet]. 2021[citado 05/07/2024]; 16(1): e0244806. Disponible en: https://doi.org/10.1371/journal.pone.0244806

11. Gómez-Sandoval JR, Robles-Cervantes JA, Hernández-González SO, Espinel-Bermudez MC, Mariaud-Schmidt R, Martínez-Rodríguez V, et al. Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. BMJ Open Diab Res Care[Internet]. 2020[citado 05/07/2024]; 8(1): e000665. Disponible en: https://doi.org/10.1136/bmjdrc-2019-000665

12. Holland R, Gomes Filho JE, Cintra LTA, Queiroz ÍODA, Estrela C. Factors affecting the periapical healing process of endodontically treated teeth. J Appl Oral Sci[Internet]. 2017[citado 05/07/2024]; 25(5): 465-76. Disponible en: https://doi.org/10.1590/1678-7757-2016-0464

13. Mohamed HG, Idris SB, Ahmed MF, Åstrøm AN, Mustafa K, Ibrahim SO, et al. Influence of type 2 diabetes on local production of inflammatory molecules in adults with and without chronic periodontitis: a cross-sectional study. BMC Oral Health[Internet]. 2015[citado 05/07/2024]; 15(1): 86. Disponible en:https://doi.org/10.1186/s12903-015-0073-z

14. Rohani B. Oral manifestations in patients with diabetes mellitus. WJD[Internet]. 2019[citado 05/07/2024]; 10(9): 485-9. Disponible en:http://dx.doi.org/10.4239/wjd.v10.i9.485

15. Mauri-Obradors E, Estrugo-Devesa A, Jane-Salas E, Vinas M, Lopez-Lopez J. Oral manifestations of Diabetes Mellitus. A systematic review. Med Oral Patol Oral Cir Bucal[Internet]. 2017[citado 05/07/2024]; 22(5): e586-94. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC5694181/pdf/medoral-22-e586.pdf

16. Yang S, Li Y, Liu C, Wu Y, Wan Z, Shen D. Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction. Front Endocrinol[Internet]. 2022[citado 05/07/2024]; 13: 949535. Disponible en: https://doi.org/10.3389/fendo.2022.949535

17. Kocher T, König J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. Periodontology 2000[Internet]. 2018[citado 05/07/2024]; 78(1): 59-97. Disponible en: https://doi.org/10.1111/prd.12235

18. Andriankaja OM, Adatorwovor R, Kantarci A, Hasturk H, Shaddox L, Levine MA. Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus. Biomedicines[Internet]. 2023[citado 05/07/2024]; 11(10): 2770. Disponible en: https://doi.org/10.3390/biomedicines11102770

19. Liccardo D, Cannavo A, Spagnuolo G, Ferrara N, Cittadini A, Rengo C, et al. Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease. Int J Mol Sci[Internet]. 2019[citado 05/07/2024]; 20(6): 1414. Disponible en: https://doi.org/10.3390/ijms20061414

20. Nibali L, Gkranias N, Mainas G, Di Pino A. Periodontitis and implant complications in diabetes. Periodontology 2000[Internet]. 2022[citado 05/07/2024]; 90(1): 88-105. Disponible en: https://doi.org/10.1111/prd.12451

21. Sangappa SB, Babu HM, Savadi RC, Krishnamurthy PT, Ravi Kiran AVVV. Salivary Interleukin-6 as a Non-Invasive Biomarker for Chronic Periodontitis and Tooth Loss in Type 2 Diabetes. Indian J Dent Res[Internet]. 2024[citado 05/07/2024]; 35(1):28-33. Disponible en: https://doi.org/10.4103/ijdr.ijdr_112_23

22. Guo LN, Yang YZ, Feng YZ. Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus. BMC Oral Health[Internet]. 2018[citado 05/07/2024]; 18(1): 63. Disponible en:https://doi.org/10.1186/s12903-018-0524-4

23. Wagner J, Spille JH, Wiltfang J, Naujokat H. Systematic review on diabetes mellitus and dental implants: an update. Int J Implant Dent[Internet]. 2022[citado 05/07/2024]; 8(1): 1. Disponible en: https://doi.org/10.1186/s40729-021-00399-8

24. Kopra E, Lahdentausta L, Pietiäinen M, Buhlin K, Mäntylä P, Hörkkö S, et al. Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers. Front Cell Infect Microbiol[Internet]. 2021[citado 05/07/2024]; 11: 774665. Disponible en:https://doi.org/10.3389/fcimb.2021.774665

25. Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, et al. Treatment of periodontitis for glycaemic control in people with diabetes mellitus. Cochrane Database of Systematic Reviews [Internet]. 2022 [citado 05/07/ 2024]; (4). Disponible en: https://doi.org/10.1002/14651858.CD004714.pub4

Published

2025-12-19

How to Cite

1.
Pérez Villalba LD, Sanchez-Solis KR, Silva-Toapanta MC, Chasi-Yugla LY. Impact of teeth whitening on dental sensitivity in patients with diabetes. Rev Ciencias Médicas [Internet]. 2025 Dec. 19 [cited 2026 Feb. 13];29(1):e6996. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/6996

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