Bone regeneration with PRP and PRF: Comparative analysis of their effectiveness in dentistry and orthopedic surgery
Keywords:
FIBRINA RICA EN PLAQUETAS; ODONTOLOGÍA; PLASMA RICO EN PLAQUETAS; PROCEDIMIENTOS ORTOPÉDICOS; REGENERACIÓN ÓSEA; REGENERACIÓN TISULAR DIRIGIDA., PLATELET-RICH FIBRIN; DENTISTRY; PLATELET-RICH PLASMA; ORTHOPEDIC PROCEDURES; BONE REGENERATION; GUIDED TISSUE REGENERATION., FIBRINA RICA EM PLAQUETAS; ODONTOLOGIA; PLASMA RICO EM PLAQUETAS; PROCEDIMENTOS ORTOPÉDICOS; REGENERAÇÃO ÓSSEA; REGENERAÇÃO TECIDUAL DIRIGIDA.Abstract
Introduction: guided bone regeneration constitutes a therapeutic cornerstone in dentistry and orthopedic surgery, where autologous platelet concentrates have gained relevance.
Objective: to evaluate the clinical effectiveness of platelet-rich plasma and platelet-rich fibrin in guided bone regeneration procedures in dentistry.
Methods: a descriptive and qualitative bibliographic review of scientific literature published between 2019 and 2024 was conducted across different databases. The design of a search algorithm enabled the identification of sources addressing the topic, and their selection according to inclusion and exclusion criteria allowed the retrieval of the necessary literature for an adequate analysis of the subject.
Development: the analyzed evidence shows that both platelet concentrates promote healing and bone regeneration. Platelet-rich plasma stands out for its ease of preparation and usefulness in complex wounds, improving postoperative recovery. In contrast, platelet-rich fibrin presents advantages in the quality and stability of regenerated tissue, attributable to its three-dimensional matrix and sustained release of growth factors. Likewise, emerging approaches, such as autologous blood clots derived from alveolar bone, were identified, broadening the available therapeutic alternatives.
Conclusions: platelet-rich plasma and platelet-rich fibrin are effective tools in guided bone regeneration. Nevertheless, platelet-rich fibrin demonstrates greater consistency in regenerative quality. Further studies are required to standardize protocols, optimize clinical indications, and consolidate comparative evidence.
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1. Zwittnig K, Mukaddam K, Végh D, Valentin H, Jakse N, Schlenke P, et al. Platelet-Rich Fibrin in Oral Surgery and Implantology: A Narrative Review. Transfus Med Hemotherapy [Internet]. 2023 [citado 22/12/2025]; 50:1-11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37767284/
2. Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, et al. Current Knowledge and Perspectives for the Use of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Oral and Maxillofacial Surgery Part 1: Periodontal and Dentoalveolar Surgery. Curr Pharm Biotechnol [Internet]. 2012 [citado 22/12/2025]; 13(7):1207-30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21740371/
3. Prakash PLC. Management of Marginal Tissue Recession using Platelet-Rich Fibrin: A Case Report. Indian J Dent Res. [Internet]. 2023[citado 22/12/2025]; 32(2): 264. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34810401/
4. González ZP, Gomes J, Torres T, Méndez R. Regeneración ósea guiada y colocación de prf y prp en paciente con enfermedad periodontal y fumador. Revisión de la literatura y presentación de un caso clínico. Más Vita [Internet].2020 [citado 22/12/2025]; 2(4): 63-73. Disponible en: https://pesquisa.bvsalud.org/fiocruz/resource/pt/biblio-1372888
5. Bettin-Yánez DL, Lopez-Arrieta Z, Bettin-Yánez DL, Lopez-Arrieta Z. Regeneración tisular guiada potencializada con fibrina rica en plaquetas en paciente con periodontitis agresiva generalizada. Reporte de un caso. CES Odontol [Internet]. 2025 [citado 22/12/2025]; 34(1): 125-35. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8055119
6. Anarthe R, Mani A, Kale P, Mustilwar R, kendre shriram. Treatment of Infrabony Defects with Platelet-Rich Fibrin: Case Report. International Journal of Innovative Science and Research Technology [Internet]. 2019 [citado 22/12/2025]; 4: 1124-8. Disponible en: https://www.ijisrt.com/assets/upload/files/IJISRT19DEC690.pdf
7. Brizuela C, Meza G, Urrejola D, Quezada A, Inostroza C, Vásquez C, et al. Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case Report. J Endod [Internet]. 2020 [citado 22/12/2025]; 46(12):1920-1927.e1. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32532626/
8. Cruz Molina C, Castro-Rodríguez Y, Cruz Molina C, Castro-Rodríguez Y. Resultados de los concentrados plaquetarios en la regeneración ósea guiada. Rev Cuba Investig Bioméd [Internet]. 2020 [citado 22/12/2025]; 39(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0864-03002020000200021&lng=es&nrm=iso&tlng=pt
9. Giacon TA, Giancola F, Paganini M, Tiengo C, Camporesi EM, Bosco G. Hyperbaric Oxygen Therapy and A-PRF Pre-Treated Implants in Severe Periodontitis: A Case Report. Int J Environ Res Public Health[Internet]. 2021 [citado 22/12/2025]; 18(2):413. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33430249/
10. Kaur H, Samal S, Vassou M, Bhatia G. CASE SERIES Clinical Research in Biomedicine and Health Care 221 Platelet Rich Plasma (PRP) Augmentation: A Novel Approach in Management of Radicular Cyst Present at Different Locations within Jaw: A Case Series. Clin Case Rep [Internet]. 2023 [citado 22/12/2025]; 2023: 221-7. Disponible en: https://www.researchgate.net/publication/370050494
11. Lafuente-Ibáñez de Mendoza I, Fernández-Reyes M, Fernández-Arenas A, Aguirre-Urizar JM. Surgical ciliated cyst after a mandibular surgery: a particular case report and review of the literature. BMC Oral Health [Internet]. 2021 [citado 22/12/2025] ;21(1):633. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34886834/
12. Mansour N, El-Sawy M. Three Years Outcome of Single Visit Orthograde Retreatment Using Platelet Concentrate: A Case Report. Journal of MAR Dental Sciences [Internet]. 2023 [citado 22/12/2025]; 7(6). Disponible en: https://www.researchgate.net/publication/376304726
13. Seco-Calvo J, Vidán-Estévez J, Sánchez-Herráez S. Successful healing of non-healing surgical wound based on the release of platelet-derived growth factors from single donor allogeneic platelet-RICH plasma with one freeze-thaw cycle: a case report after a 1-year follow-up. Transl Med Commun [Internet]. 2022 [citado 22/12/2025]; 7(14): 14. Disponible en: https://link.springer.com/article/10.1186/s41231-022-00120-w
14. Sisto DMP. Lesión endoperiodontal tratada con plasma rico en plaquetas. Informe de caso. MEDISAN [Internet]. 2022 [citado 22/12/2025]; 25(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192021000200305
15. Xu M, Sun XY, Xu JG. Periodontally accelerated osteogenic orthodontics with platelet-rich fibrin in an adult patient with periodontal disease: A case report and review of literature. World J Clin Cases [Internet]. 2021 [citado 22/12/2025]; 9(6): 1367-78. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33644204/
16. Wu Q. Regenerative endodontic treatment using autologous blood from alveolar bone for mature permanent premolar with apical periodontitis: a case report. Clin Oral Investig [Internet]. 2023 agosto [citado 22/12/2025]; 27(8): 4869-74. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37481641/
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