Efficacy of platelet-rich plasma in the regeneration of periodontal tissues
Keywords:
PERIODONCIA; PLASMA RICO EN PLAQUETAS; REGENERACIÓN TISULAR DIRIGIDA., PERIODONTICS; PLATELET-RICH PLASMA; GUIDED TISSUE REGENERATION., PERIODONTIA; PLASMA RICO EM PLAQUETAS; REGENERAÇÃO TECIDUAL GUIADA.Abstract
Introduction: periodontitis causes loss of dental supporting tissues and represents a clinical challenge for regenerative dentistry, where safe and effective biological alternatives are sought.
Objective: to analyze the effectiveness of platelet-rich plasma (PRP) in periodontal regeneration, describing its clinical applications and its impact on healing and revascularization.
Methods: a systematic review of the scientific literature was conducted across multiple databases. The search employed an algorithm combining keywords and Boolean operators to identify relevant sources. Selected studies, after applying inclusion and exclusion criteria, were critically analyzed considering recency, methodological quality, and thematic relevance, and integrated into the final synthesis of the review.
Development: reviewed studies demonstrate that PRP acts as a reservoir of growth factors, promoting angiogenesis, cell proliferation, and bone regeneration. Benefits have been reported in regenerative endodontics, oral surgery, and periodontics, including pain reduction, accelerated healing, and improved graft integration. Its safety and low incidence of adverse effects are also highlighted. However, challenges remain regarding standardization of preparation protocols and evaluation of long-term outcomes.
Conclusions: platelet-rich plasma constitutes a promising biomaterial in periodontal regeneration, with clinical advantages in healing and revascularization. Its efficacy is supported by multiple studies, although comparative and longitudinal research is needed to consolidate standardized protocols and assess its sustained impact in dental practice.
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