Fixed dental prostheses with controlled therapeutic drug release
Keywords:
IMPLANTES DENTALES; LIBERACIÓN DE FÁRMACOS; SALUD BUCAL.; DENTAL IMPLANTS; DRUG LIBERATION; ORAL HEALTH.; IMPLANTES DENTÁRIOS; LIBERAÇÃO CONTROLADA DE FÁRMACOS; SAÚDE BUCAL.Abstract
Introduction: fixed dental prostheses have improved oral rehabilitation, but peri-implant infections remain a challenge that compromises the health and longevity of implants.
Objective: to evaluate the effectiveness of controlled drug release systems in fixed prostheses to reduce infections and prolong implant durability.
Methods: a systematic review of the scientific literature was conducted across different databases, using an algorithm with keywords and Boolean operators to identify relevant sources. The selected studies, after applying rigorous inclusion and exclusion criteria, were critically assessed in terms of timeliness, methodological quality, and thematic relevance, and coherently integrated into the final synthesis of the review.
Development: the reviewed studies show that implants with controlled release reduce the incidence of infections by 35 % to 50 % compared to conventional ones. They also increase success and osseointegration rates, thanks to localized release of antibiotics and bioactive biomaterials. A combined relative risk of 0,39 was reported, confirming preventive efficacy. The integration of nanomaterials, hydroxyapatite, and supramolecular systems enhances bone regeneration and immune response, consolidating this innovation as a promising strategy in restorative dentistry.
Conclusions: controlled drug release in fixed prostheses significantly decreases peri-implant infections and improves implant longevity. These findings support its incorporation into clinical practice as a relevant advance in oral health and prosthetic rehabilitation.
Downloads
References
1. Sáez V, Hernáez E, Sanz Angulo L. Sistemas de liberación controlada de medicamentos. Rev Iberoam Polímeros [Internet]. 2020 [citado 26/08/2025]; 3(3):16-23. Disponible en: https://reviberpol.org/wp-content/uploads/2019/08/2003-saez-1.pdf
2. Gallucci GO, Hamilton A, Zhou W, Buser D, Chen S. Implant placement and loading protocols in partially edentulous patients: a systematic review. Clin Oral Implants Res [Internet]. 2018 [citado 26/08/2025]; 29(S16):106-134. https://doi.org/10.1111/clr.13276
3. Ali Z, Baker SR, Shahrbaf S, Martin N, Vettore MV. Oral health-related quality of life after prosthetic rehabilitation for patients with partial edentulism: A systematic review and meta-analysis. J Prosthet Dent [Internet]. 2019 [citado 26/08/2025]; 121(1): 59-68e3. Disponible en: https://doi.org/10.1016/j.prosdent.2018.03.003
4. Sandoval Pedauga S, Carrasco Sierra M, Reyes Pico GJ. Rehabilitación con prótesis fija. Salud y Vida [Internet]. 2019 [citado 26/08/2025]; 3(6):690-707. Disponible en: http://dx.doi.org/10.35381/s.v.v3i6.333
5. Kwon T, Bain PA, Levin L. Revisión sistemática de la supervivencia y el éxito a corto (5-10 años) y largo plazo (10 años o más) de prótesis dentales híbridas fijas de arcada completa e implantes de soporte. J Dent [Internet]. 2014 [citado 26/08/2025]; 42(10):1228–1241. Disponible en: https://doi.org/10.1016/j.jdent.2014.05.016
6. Hakim LK, Yari A, Nikparto N, Mehraban SH, Cheperli S, Asadi A, et al. The current applications of nano and biomaterials in drug delivery of dental implant. BMC Oral Health [Internet]. 2024 [citado 26/08/2025]; 24(1):126. Disponible en: https://doi.org/10.1186/s12903-024-03911-9
7. Alécio ABW, Ferreira CF, Babu J, Shokuhfar T, Jo S, Magini R, et al. Doxycycline Release of Dental Implants With Nanotube Surface, Coated With Poly Lactic-Co-Glycolic Acid for Extended pH-controlled Drug Delivery. J Oral Implantol [Internet]. 2019 [citado 26/08/2025]; 45(4):267-273. Disponible en: https://doi.org/10.1563/aaid-joi-d-18-00069
8. Freischmidt H, Armbruster J, Rothhaas C, Titze N, Guehring T, Nurjadi D, et al. Efficacy of an Antibiotic Loaded Ceramic-Based Bone Graft Substitute for the Treatment of Infected Non-Unions. Biomedicines [Internet]. 2022 [citado 26/08/2025]; 10(10):2513. Disponible en: https://doi.org/10.3390/biomedicines10102513
9. Gulati K, Hamlet SM, Ivanovski S. Tailoring the immuno-responsiveness of anodized nano-engineered titanium implants. J Mater Chem B [Internet]. 2018 [citado 26/08/2025]; 6(18):2677-2689. Disponible en: https://doi.org/10.1039/c8tb00450a
10. Sbricoli L, Guazzo R, Annunziata M, Gobbato L, Bressan E, Nastri L. Selection of Collagen Membranes for Bone Regeneration: A Literature Review. Materials (Basel) [Internet]. 2020 [citado 26/08/2025]; 13(3):786. Disponible en: https://doi.org/10.3390/ma13030786
11. Shokuhfar T, SinhaRay S, Sukotjo C, Yarin AL. Intercalation of anti-inflammatory drug molecules within TiO₂ nanotubes. RSC Adv [Internet]. 2013 [citado 26/08/2025]; 3:173806. Disponible en: https://doi.org/10.1039/C3RA42173B
12. Kavoosi F, Modaresi F, Sanaei M, Rezaei Z. Medical and dental applications of nanomedicines. APMIS [Internet]. 2018 [citado 26/08/2025]; 126(10):795–803. Disponible en: https://doi.org/10.1111/apm.12890
13. Munir MU, Ihsan A, Sarwar Y, Bajwa SZ, Bano K, Tehseen B, et al. Hollow mesoporous hydroxyapatite nanostructures; smart nanocarriers with high drug loading and controlled releasing features. Int J Pharm [Internet]. 2018 [citado 26/08/2025]; 544(1):112-120. Disponible en: https://doi.org/10.1016/j.ijpharm.2018.04.029
14. Li H, Zhong H, Xu K, Yang K, Liu J, Zhang B, et al. Enhanced efficacy of sirolimus-eluting bioabsorbable magnesium alloy stents in the prevention of restenosis. J Endovasc Ther [Internet]. 2011 [citado 26/08/2025]; 18(3):407-15. Disponible en: https://doi.org/10.1583/10-3353.1
15. Moseke C, Hage F, Vorndran E, Gbureck U. TiO2 nanotube arrays deposited on Ti substrate by anodic oxidation and their potential as a long-term drug delivery system for antimicrobial agents. Appl Surf Sci [Internet]. 2012 [citado 26/08/2025]; 258(14): 5399-5404. Disponible en: https://doi.org/10.1016/j.apsusc.2012.02.022
16. Shayeb MA, Elfadil S, Abutayyem H, Shqaidef A, Marrapodi MM, Cicciù M, et al. Bioactive surface modifications on dental implants: a systematic review and meta-analysis of osseointegration and longevity. Clin Oral Investig [Internet]. 2024 [citado 26/08/2025]; 28(11):592. Disponible en: https://doi.org/10.1007/s00784-024-05958-y
17. Anil S, Al-Sulaimani AF, Beeran AE, Chalisserry EP, Varma HP, Al Amri MD. Drug delivery systems in bone regeneration and implant dentistry. En: Turkylmaz I. Current concepts in dental implantology. 1ra Ed. Rijeka: IntechOpen. 2015 [consultado 26/08/2025]. Disponible en: https://dx.doi.org/10.5772/58668
18. Szwed-Georgiou A, Płociński P, Kupikowska-Stobba B, Urbaniak MM, Rusek-Wala P, Szustakiewicz K, et al. Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems. ACS Biomater Sci Eng [Internet]. 2023 [citado 26/08/2025]; 9(9):5222-5254. Disponible en: https://doi.org/10.1021/acsbiomaterials.3c00609
19. Wang S, Liu R, Fu Y, Kao WJ. Release mechanisms and applications of drug delivery systems for extended-release. Expert Opin Drug Deliv [Internet]. 2020 [citado 26/08/2025]; 17(9):1289-1304. Disponible en: https://doi.org/10.1080/17425247.2020.1788541
20. Alshimaysawee S, Fadhel Obaid R, Al-Gazally ME, Alexis Ramírez-Coronel A, Bathaei MS. Recent Advancements in Metallic Drug-Eluting Implants. Pharmaceutics [Internet]. 2023 [citado 26/08/2025]; 15(1):223. Disponible en: https://doi.org/10.3390/pharmaceutics15010223
21. Waghmare G, Waghmare K, Bagde S, Deshmukh M, Kashyap DN, Shahu VT. Materials Evolution in Dental Implantology: A Comprehensive Review. Journal of Advanced Research in Applied Mechanics [Internet]. 2024 [citado 26/08/2025]; 123(1): 75-100. Disponible en: https://doi.org/10.37934/aram.123.1.75100
22. Moon KS, Park YB, Bae JM, Oh S. Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod-sputtered titania nanotubes. J Tissue Eng [Internet]. 2018 [citado 26/08/2025]; 9:2041731418790315. Disponible en: https://doi.org/10.1177/2041731418790315
23. van Oirschot BAJA, Zhang Y, Alghamdi HS, Cordeiro JM, Nagay BE, Barao VAR, et al. Surface Engineering for Dental Implantology: Favoring Tissue Responses Along the Implant. Tissue Eng Part A [Internet]. 2022 [citado 26/08/2025]; 28(11-12):555-572. Disponible en: https://doi.org/10.1089/ten.tea.2021.0230
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Noemí Estefanía Morales Morales
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
