Cannabis and its influence on cellular stability and tissue integrity: analysis of cell lysis and cell death markers
Keywords:
ABUSO DE MARIHUANA; CANNABIS; INFLAMACIÓN; TRASTORNOS RELACIONADOS CON SUSTANCIAS; MUERTE CELULAR.; MARIJUANA ABUSE; CANNABIS; INFLAMMATION; SUBSTANCE-RELATED DISORDERS; CELL DEATH.; ABUSO DE MACONHA; CANNABIS; INFLAMAÇÃO; TRANSTORNOS RELACIONADOS AO USO DE SUBSTÂNCIAS; MORTE CELULAR.Abstract
Introduction: cannabis consumption has been the subject of growing scientific interest due to its effects on cellular stability and tissue integrity, with relevant implications for public health.
Objective: to analyze the available evidence on the effects of cannabis on cell lysis, inflammation, and tissue degeneration in vital organs.
Methods: a systematic review of the scientific literature was conducted across various databases. The search was carried out using an algorithm with keywords and Boolean operators, allowing the identification of relevant sources. The selected studies, after applying inclusion and exclusion criteria, were critically analyzed considering timeliness, methodological quality, and thematic relevance, and integrated into the final synthesis of the review.
Development: tetrahydrocannabinol affects neuroplasticity and neuronal homeostasis, generating cognitive and structural alterations in the brain. In the liver, CB1 receptor activation promotes inflammatory processes and fibrosis, while in the cardiovascular system arrhythmias, orthostatic hypotension, and risk of heart failure have been reported. Findings also show an increase in reactive oxygen species and endothelial dysfunction, compromising cell viability. Although some studies suggest beneficial immunomodulatory effects, the prevailing evidence highlights negative consequences on organ function and tissue integrity.
Conclusions: cannabis exerts adverse effects on cellular stability and the integrity of essential organs, promoting inflammatory and degenerative processes. These findings reinforce the need for further research and preventive strategies that consider neurological, cardiovascular, and hepatic risks.
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