Use of enamel matrix–derived proteins in periodontal procedures: Clinical evaluation of Emdogain
Keywords:
HUESOS; PERIODONCIA; PROTEÍNAS; REGENERACIÓN.; : BONE AND BONES; PERIODONTICS; PROTEINS; REGENERATION.Abstract
Introduction: chronic periodontitis compromises the supporting dental tissues, generating interest in regenerative biomaterials such as Emdogain.
Objective: to analyze the clinical efficacy of Emdogain in periodontal procedures and its impact on tissue regeneration.
Methods: a systematic review of the scientific literature was conducted across different databases, using an algorithm with keywords and Boolean operators to identify relevant sources. The selected studies, after applying rigorous inclusion and exclusion criteria, were critically evaluated regarding timeliness, methodological quality, and thematic relevance, and coherently integrated into the final synthesis of the review.
Development: evidence shows that Emdogain promotes the formation of new periodontal ligament, root cementum, and alveolar bone. Clinical studies reported an average reduction of 3,5 mm in periodontal pockets and a gain of 2,8 mm in clinical attachment. Its application is associated with lower morbidity, improved healing, and absence of additional surgeries. Compared with other biomaterials, Emdogain demonstrated superiority, especially when combined with connective tissue grafts. However, its efficacy decreases in extensive periodontal defects and in smokers, limiting its predictability in complex cases.
Conclusions: emdogain represents an effective and less invasive alternative for periodontal regeneration, with favorable clinical and histological outcomes. Nevertheless, further research is required to optimize its application and define combined protocols for complex defects.
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