Factors associated with persistent post-Covid-19 symptoms in adult patients

Authors

Keywords:

Factores de riesgo; Covid-19; Síndrome post agudo de Covid-19; Pacientes; Adulto; Signos y síntomas

Abstract

Introduction: Patients who have suffered from Covid-19 disease tend to recover, but there is a proportion who continue to present persistent symptoms; therefore, it is important to identify their associated factors.

Objective: Determine the factors associated with persistent post-Covid-19 symptoms in adult patients treated at the Ate Vitarte Emergency Hospital, 2021.

Methods: Observational, non-experimental, quantitative, case-control and retrospective study. The sample was 214 adult patients, of which 107 were from the case group and 107 from the control group; The sampling was systematic probabilistic. Statistical analyzes were performed using the Chi square test and binary logistic regression. Approval was obtained from the hospital ethics committee.

Results: According to the bivariate analysis, age from 36 to 65 years (p=0,000; OR=3,518), presenting at least one comorbidity (p=0,002; OR=2,596), having vaccines against Covid-19 (p=0,001; OR=14,660), obese (p=0,023; OR=1,920), presenting severe initial Covid-19 (p=0,000; OR=4,062), oxygen therapy (p=0,002; OR=2,765) and admission to the ICU (p =0,005; OR=2,360) were significantly associated with persistent post-Covid-19 symptoms. However, the multivariate analysis finally demonstrated that age from 36 to 65 years (p=0,004; ORa=4,918) and the presence of at least one comorbidity (p=0,010; ORa=2,738) were factors significantly associated with persistent symptoms post-Covid-19.

Conclusions: There are factors significantly associated with persistent post-Covid-19 symptoms; stories like the age of 36 to 65 years and having comorbidities.

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References

1. Pan American Health Organization. La OMS caracteriza a COVID-19 como una pandemia [Internet]. Washington, D.C.: PAHO; 2020 [consultado 24/02/2026]. Disponible en: https://www.paho.org/es/noticias/11-3-2020-oms-caracteriza-covid-19-como-pandemia

2. Wang C, Wang Z, Wang G, Lau JY, Zhang K, Li W. COVID-19 in early 2021: current status and looking forward. Signal Transduct Target Ther [Internet]. 2021 [citado 24/02/2026]; 6(1):114. Disponible en: https://doi.org/10.1038/s41392-021-00527-1

3. Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol [Internet]. 2020 [citado 24/02/2026]; 215:108427. Disponible en: https://doi.org/10.1016/j.clim.2020.108427

4. Peralta G, Carozzo T, Sierra M, Bu E. Enfermedad por coronavirus (COVID-19): la pandemia según la evidencia actual. INNOVARE [Internet]. 2020 [citado 24/02/2026]; (1): 15-27. Disponible en: https://revistas.unitec.edu/innovare/article/view/108

5. Cieza Zevallos J, Uriol Lescano C. Letalidad y la mortalidad de Covid 19 en 60 países afectados y su impacto en los aspectos demográficos, económicos y de salud. Rev Méd Hered [Internet]. 2021 [citado 24/02/2026]; 31(4):214-21. Disponible en: https://revistas.upch.edu.pe/index.php/RMH/article/view/3852

6. Díaz-Castrillón FJ, Toro-Montoya AI. SARS-CoV-2/COVID-19: el virus, la enfermedad y la pandemia. Medicina & Laboratorio [Internet]. 2020 [citado 24/02/2026]; 24(3): 183-205. Dipsonible en: https://www.medigraphic.com/pdfs/medlab/myl-2020/myl203b.pdf

7. Donders F, Lonnée-Hoffmann R, Tsiakalos A, Mendling W, Martinez de Oliveira J, Judlin P, et al. ISIDOG Recommendations Concerning COVID-19 and Pregnancy. Diagnostics (Basel) [Internet]. 2020 [citado 24/02/2026]; 10(4):243. Disponible en: https://doi.org/10.3390/diagnostics10040243

8. World Health Organization. Afección pos-COVID-19 (COVID-19 prolongada) [Internet]. Geneva: WHO; 2025 [consultado 24/02/2026]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/post-covid-19-condition-(long-covid)

9. Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol [Internet]. 2023 [citado 24/02/2026]; 21(3):133-146. Disponible en: https://doi.org/10.1038/s41579-022-00846-2

10. Al-Aly Z, Davis H, McCorkell L, Soares L, Wulf-Hanson S, Iwasaki A, Topol EJ. Long COVID science, research and policy. Nat Med [Internet]. 2024 [citado 24/02/2026]; 30(8):2148-2164. Disponible en: https://doi.org/10.1038/s41591-024-03173-6

11. Fumagalli C, Zocchi C, Tassetti L, Silverii MV, Amato C, Livi L, et al. Factors associated with persistence of symptoms 1 year after COVID-19: A longitudinal, prospective phone-based interview follow-up cohort study. Eur J Intern Med [Internet]. 2022 [citado 24/02/2026]; 97:36-41. Disponible en: https://doi.org/10.1016/j.ejim.2021.11.018

12. Chopra V, Flanders SA, O'Malley M, Malani AN, Prescott HC. Sixty-day outcomes among patients hospitalized with COVID-19. Ann Intern Med [Internet]. 2021 [citado 24/02/2026]; 174(4):576-578. Disponible en: https://doi.org/10.7326/m20-5661

13. Mauricio Trelles PB, Gutierrez Cadillo DN. Caracterización clínica epidemiológica de las secuelas Covid-19 en adultos recuperados de un hospital de Huancayo. Rev Peru Cienc Salud [Internet]. 2022 [citado 24/02/2026]; 4(1): 9-15. Disponible en: http://revistas.udh.edu.pe/RPCS/article/view/364e

14. World Health Organization. Global COVID-19 Clinical Platform Case Report Form (CRF) for Post COVID condition (Post COVID-19 CRF) [Internet]. Geneva: WHO; 2021 [consultado 24/02/2026]. Disponible en: https://www.who.int/publications/i/item/global-covid-19-clinical-platform-case-report-form-(crf)-for-post-covid-conditions-(post-covid-19-crf-)

15. Unidad de Análisis y Generación de evidencias en Salud Pública. Nota Técnica COVID-19 N°022-2022: Prevalencia, manifestaciones clínicas y factores asociados al desarrollo de COVID-19 de larga duración [Internet]. Lima: Instituto Nacional de Salud; 2022 [consultado 24/02/2026]. Disponible en: https://docs.bvsalud.org/biblioref/2022/05/1369443/nt_22_longcovid.pdf

16. de la Calle Castro A, Tello Carhuanca R, Villegas Felix T, Suasnabar E. Factores de comorbilidad y secuelas de COVID-19 en trabajadores de un Hospital Nacional de Huancayo 2021. Visionarios en ciencia y tecnología [Internet]. 2021 [citado 24/02/2026]; 6(1): 111-121. Disponible en: https://doi.org/10.47186/visct.v6i2.97

17. Hossain MA, Hossain KMA, Saunders K, Uddin Z, Walton LM, Raigangar V, et al. Prevalence of Long COVID symptoms in Bangladesh: a prospective Inception Cohort Study of COVID-19 survivors. BMJ Glob Health [Internet]. 2021 [citado 24/02/2026]; 6(12): e006838. Disponible en: https://doi.org/10.1136/bmjgh-2021-006838

18. Leung JM, Niikura M, Yang CWT, Sin DD. COVID-19 and COPD. Eur Respir J [Internet]. 2020 [citado 24/02/2026]; 56(2):2002108. Disponible en: https://doi.org/10.1183/13993003.02108-2020

19. Boglione L, Meli G, Poletti F, Rostagno R, Moglia R, Cantone M, et al. Risk factors and incidence of long-COVID syndrome in hospitalized patients: does remdesivir have a protective effect? QJM [Internet]. 2022 [citado 24/02/2026]; 114(12):865-871. Disponible en: https://doi.org/10.1093/qjmed/hcab297

20. Iqbal A, Iqbal K, Arshad Ali S, Azim D, Farid E, Baig MD, et al. The COVID-19 Sequelae: A Cross-Sectional Evaluation of Post-recovery Symptoms and the Need for Rehabilitation of COVID-19 Survivors. Cureus [Internet]. 2021 [citado 24/02/2026]; 13(2): e13080. Disponible en: https://doi.org/10.7759/cureus.13080

21. Mahmud R, Rahman MM, Rassel MA, Monayem FB, Sayeed SKJB, Islam MS, et al. Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh. PLoS One [Internet]. 2021 [citado 24/02/2026]; 16(4): e0249644. Disponible en: https://doi.org/10.1371/journal.pone.0249644

Published

2026-09-27

How to Cite

1.
Pomayay-Yaranga NJ, Vásquez-Alva R. Factors associated with persistent post-Covid-19 symptoms in adult patients . Rev Ciencias Médicas [Internet]. 2026 Sep. 27 [cited 2026 Oct. 6];30(1):e7260. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/7260

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Section

ORIGINAL ARTICLES