Detection Increase of cervix lesions by means of visual examination in Puerto Esperanza, 2008

Authors

  • José Guillermo Sanabria Negrín Especialista de Segundo Grado en Histología. Dr. C Biológicas. Profesor Auxiliar. Universidad de Ciencias Médicas Pinar del Río.
  • Víctor E. Salgueiro Medina Especialista de Segundo Grado en Obstetricia y Ginecología. Ms C. Atención Integral a la Mujer. Asistente. Hospital General Docente Abel Santamaría Cuadrado.
  • Magalys B. Abreu Mérida Especialista de Segundo Grado en Obstetricia y Ginecología. Ms C. Atención Integral a la Mujer. Profesora Auxiliar. Universidad de Ciencias Médicas de Pinar del Río.
  • Catty Vólquez Especialista de Primer Grado en Medicina General Integral. Universidad de Ciencias Médicas de Pinar del Río.

Keywords:

Precancerous conditions, Cervix uteri, Cytodiagnosis, Uterine cervical neoplasms, Coldposcopía.

Abstract

Visual examination of cervix using acetic acid up to 4-5% (VIA) and Lugol's solution (VILI) contribute to detect lesions. This constitutes the first report of their use in Cuba.
Objective: to demonstrate the detection increase of pre-malignant and malignant cervical lesions by means of visual examination in Primary Health Care.
Method
: control-case studies in Puerto Esperanza, Viñales municipality in 2008.
Target group
: women from 15 to 64 years old who practice penetrating sexual relations. Sample: women who underwent visual examinations and altered cytology (n1= 18 cases) or not (n2= 178 controls). In Cervix Pathology Office, colposcopies either by directed biopsy or conization with diathermal ansa were practiced; calculating absolute and relative percentage frequencies and the probability to detect lesions by isolated tests or in set, together with the tests of diagnostic performance.
Results: VIA and VILI were positive in 92.9% and 79.6%, respectively. The joint probability of presenting lesions was 0. 7395. Those showing altered cytology (88.9%) had positive VIA and 77, 9% positive VILI. Colposcopy resulted positive in 70.9% and the probability of having a lesion, proved by visual examination, simultaneously with colposcopy was 0.516. Biopsies performed to 136 women were useful (99.3%), out of them, almost 50% presented pre-malignant and malignant lesions. Yield tests were superior to VIA and VILI than to cytology. Non-invasive cancer was detected; however in situ carcinoma was. Conclusion: visual examination increased the number of diagnosis 4 times, thus its use must be generalized.

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References

1. Arrossi S, Sankaranarayana R, Parkin DM. Incidence and mortality of cervical cancer in Latin America. Salud Publica Mex 2003; 45 (Supp 3): S306-S314. Acceso el 22-05-05. Disponible en: http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0036-36342003000900004

2. Ferlay J, Bray F, Pisani P, Parkin DM. Global cancer statistics 2002. CA Cancer J Clin[on line]2005[cited january 2011];55:74–108. Available from: http://onlinelibrary.wiley.com/doi/10.3322/canjclin.55.2.74/pdf

3. Pillai MR, Hariharan R, Babu JM, Lakshmi S, Chiplunkar SV, Patkar M, Tongaonkar H, Dinshaw K, Jayshree RS, Reddy BK, Siddiqui M, Roychoudury S, Saha B, Abraham P, Gnanamony M, Peedicayil A, Subhashini J, Ram TS, Dey B, Sharma C, Jain SK, Singh N. Molecular variants of HPV-16 associated with cervical cancer in Indian population. Int J Cancer 2009 Jul 1; Vol. 125 (1), pp. 91-103. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19358280/

4. Guzman VB, Wambartsev A, Gonzalves-Primo A, Silva IDCG, Carvalho CRN, Ribalta JCL, Goulart LR, Shulzhenko N, Gerbase-De Lima M, Morgun A. New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. Human Molecular Genetics 2008 17(12):1838-1844; doi:10.1093/hmg/ddn077. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536747/

5. Shiffmann M, Castle PE. The Promise of Global Cervical Cancer Prevention. New England Journal Medicine, 2005; 353 (20): 2101-2104. Acceso 26-02-06. Disponible en: http://dceg.cancer.gov/Files/schiffman35321012005.pdf

6. Murillo R, Almonte M, Pereira A, Ferrer E, Gamboa OA, Jerónimo J, Lazcano-Ponce E.. Cervical cancer screening programs in Latin America and the Caribbean. Vaccine. 2008 Aug 19;26 Suppl 11:L37-48. Acceso 26-02-09 Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/18945401

7. Peevor R; Bowden S; Jones J; Fiander AN; Hibbitts S. Human Papillomavirus negative but dyskaryotic cervical cytology: re-analysis of molecular testing. J Clin Virol 2009 Apr; Vol. 44 (4): 322-4. Acceso 17-05-09. Disponible en: http://www.esbscohost.org/

8. Johnson CE, Mues KE, Mayne SL, Kiblawi AN. Cervical cancer screening among immigrants and ethnic minorities: a systematic review using the Health Belief Model. J Low Genit Tract Dis. 2008 Jul;12(3):232-41, Acceso 14-08-10 en: http://www.ncbi.nlm.nih.gov/pubmed/18596467 ?

9. Watts L, Joseph N, Velazquez A, Gonzalez M, Munro E, Muzikansky A, Rauh-Hain JA, Del Carmen MG. Understanding barriers to cervical cancer screening among Hispanic women. Am J Obstet Gynecol. 2009 Aug;201(2):199.e1-8 Acceso 03-09-09 en: http://www.ncbi.nlm.nih.gov/pubmed/19646571 ?

10. Wiesner-Ceballos C, Vejarano-Velandia M, Caicedo-Mera JC, Tovar-Murillo SL, Cendales-Duarte R. [Cervical cytology in Soacha, Colombia: social representation, barriers and motivation] Rev Salud Publica (Bogota). 2006 Sep-Dec;8(3):185-96.Acceso 10-03-07 Disponible en: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17269218

11. MINSAP, Cuba. Programa Nacional de Detección Precoz del Cáncer Cervicouterino. La Habana, Cuba, 1968.

12. Herrera Pérez MA, Cirión Martínez G, Sanabria-Negrín JG. Control de la calidad de los exámenes citológicos en el primer trimestre del año 2005 en el Hospital Universitario "Abel Santamaría Cuadrado". Pinar del Río. VII Congreso Virtual Hispanoamericano de Anatomía Patológica. España, 2005: Disponible en:http://www.conganat.org/7congreso/PDF/pdf

13. Sanabria Negrín JG, Herrera Díaz MA, Abreu Mérida M, Salgueiro Medina V, Palacios Valdés G. Sensibilidad y especificidad de la citología orgánica cervical. Pinar del Río, 2005. VII Congreso Virtual Hispanoamericano de Anatomía Patológica. España. Oct. 2005. Ref. 450. Disponible en: http://www.conganat.org/7congreso/PDF/450.pdf

14. Pinar del Río. Datos del Registro Provincial de Cáncer, y del Registro de Mortalidad, Dpto Provincial de Estadísticas de Pinar de Río.

15. Belinson JL, Pretorius RG, Zhang WH, Wu LY, Qiao YL, Elson P. Cervical cancer screening by simple visual inspection after acetic acid. Obstet Gynecol 2001; 98: 441-444. Ref. Acceso 22-05-07 Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11530126

16. Jeronimo J, Morales O, Horna J, Pariona J, Manrique J, Rubiños J, Takahashi R. Visual inspection with acetic acid for cervical cancer screening outside of low-resource settings. Rev Panam Salud Publica 2005; 17 (1): 1- 5. Disponible en: http://www.scielosp.org/scielo.php?pid=S1020-49892005000100001&script=sci_arttext

17. Sankaranarayanaan R, Ramani WS. A Practical Manual on visual screening for cervical neoplasia. Lyon, France Publicación Técnica del CIIC No. 41. 2003

18. Shastri SS, Dinshaw K, Amin G, Goswami S, Patil S, Chinoy R, Kane S, Kelkar R, Muwonge R, Mahe C, Ajit D, Sankaranarayanan R. Concurrent evaluation of visual, cytological and HPV testing as screening methods for the early detection of cervical neoplasia in Mumbai, India. Bull World Health Organ. 2005 Mar;83(3):186-94. Disponible en http://www.scielosp.org/scielo.php?pid=S0042-96862005000300011&script=sci_arttext

19. Sankaranarayanan R, Wesley RS. Manual práctico para la detección visual de las neoplasias cervicales. Publicación Técnica del CHC No. 41. IARC Press 2005.

20. Sankaranarayanan R, Wesley RS, Thara S, Dhakad N, Chandralekha B, Sebastian P, Chithrathara K, Parkin DM, Krishnan Fair M. Test characteristics of visual inspection with 4 % acetic acid (VIA) and Lugol´s iodine (VILI) in cervical cancer screening in Kerala, India. Int J Cancer 2003; 106: 404-408. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002 /ijc.11245/full

21. Solomon D, Davey D, Kurman R, Moriarty A, O´Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T Jr. Young N, Forum Group Members; Bethesda 2001 Workshop.Bethesda System 2001. JAMA 2002 Apro24, 287 (16): 2114- 2119. Disponible en: http://www.urmc.rochester.edu/smd/gme/prospective/obgyn/documents/bethesda.pdf

22. Richart RM. Cervical intraepithelial neoplasia. Pathol Ann 1973; 8:301_28. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/4583016

23. MINSAP. Colectivo de autores. Programa de Detección Precoz del Cáncer cervicouterino. Cuba. 2001.

24. Belinson J, Qiao YL, Pretorius R, Zhang WH, Elson P, Li L. Shanxi Province cervical cancer screening study: a cross sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecol Oncol 2001;83:439_444. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11606114

25. Sankaranarayanan R, Nene BM, Dinshaw K, Rajkumar R, Shastri S, Wesley R, Basu P, Sharma R, Thara S, Budkh A, Parkin DM. Early detection of cervical cancer with visual inspection methods: A summary of completed and on-going studies in India. Salud Publica Mex 2003; 45 Supp 3:S399-S407. Disponible en: http://www.scielo.org.mx/pdf/spm/v45s3/v45s3a14.pdf

26. Mowonge R, da Ganda Manuel M, Filipe AP, Bernardo Dumas J, Ranque Frank M, Sankaranarayan R. Visual screening for early detection of cervical neoplasia in Angola. International Journal of Gynecology and Obstetrics 2010 October, 111 (1): 68-72, Acceso 31-05-11 en: http://www.ijgo.org/article/S0020-7292(10)00230-4

27. Sangwa-Lugoma G, Mahmud S, Nasr SH, Liaras J, Kayembe PK, Tozin RR, Drouin P, Lorincz A, Ferenczy A, Franco EL. Visual inspection as a cervical cancer screening method in a primary health care setting in Africa. Int J Cancer. 2006 Sep 15;119(6):1389-95.iodine (VILI) in cervical cancer screening in Kerala, India. Int J Cancer 2003; 106: 404-408. Acceso 20-03-08. Disponible en: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16619217

28. Sauvet C, Fayette JM, Mowonge R, Wesley R, Sankaranarayan R. Accuracy of visual inspection with acetic acid for cervical cancer screening. International Journal of Gynecology & Obstetrics. 2011 April, 113 (1): 14-24, Disponible en: http://www.ijgo.org/article/S0020-7292(10)00579-5

29. Vedantham H, Silver MI, Kalpana B, Rekha C, Karuna BP, Vidyadhari K, Mrudula S, Ronnett BM, Vijayaraghavan K, Ramakrishna G, Sowjanya P, Laxmi S, Shaht KV, Gravitt PE for the CATCH Study Team. Determinants of VIA (Visual inspection of the cervix after acetic acid application) positivity in cervical cancer screening of women in a peri-urban area in Andhra Pradesh, India. Cancer Epidemiology, Biomarkers & Prevention 2010; 19: 1373. Acceso 14-04-2011 Disponible en: http://cebp.aacrjournals.org/content/19/5/1373

30. Znaor A, Strnad M. Cervical cancer in Croatia: state of the art and possibilities for prevention.Znaor A, Strnad M. Coll Antropol. 2007 Apr; 31 Suppl 2:37-40. Acceso 14-08-10 Disponible en: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17598503

Published

2011-10-01

How to Cite

1.
Sanabria Negrín JG, Salgueiro Medina VE, Abreu Mérida MB, Vólquez C. Detection Increase of cervix lesions by means of visual examination in Puerto Esperanza, 2008. Rev Ciencias Médicas [Internet]. 2011 Oct. 1 [cited 2025 Sep. 16];15(3):81-98. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/801

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ORIGINAL ARTICLES