Myasthenic crisis associated with `Influenza' A (H1N1) virus. A case report
Keywords:
Influenza' A (H1N1), Myasthenia gravis, Myasthenic crisis.Abstract
The infection with seasonal influenza is very common, though it is a prevailing cause of respiratory disease; it has been associated with a variety of neurological complications. However, many cases having neurological complications are not described related to `Influenza' A (H1N1) virus. A case of myasthenic crisis associated with `Influenza' A (H1N1) virus was presented. A 24 year-old female patient was admitted in the otolaryngology service at "Abel Santamaria Cuadrado" University Hospital suffering from rhinolalia, dysphagia and four days of fever followed by acute respiratory failure together with quadriparesis. Through several complementary examinations it was possible to diagnose an infection caused by `Influenza' A (H1N1) virus and myasthenia gravis. Antibiotic-therapy (cefotaxime, amikacin and metronidazole), oseltamivir and intacglobin 400mg/Kg during 5 days was the treatment followed, as the patient showed a marked improvement of the respiratory sepsis and motor defect she was then weaned. The patient was transferred to an internal medicine ward to follow a treatment with prednisone and piridostigmine, having a favorable progress.Downloads
References
1. Baltagi SA, Shoykhet M, Felmet K, Kochanek PM, Bell MJ. Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic. Pediatr Crit Care Med. 2010; 11(2): p.179-84.
2. Lang B, Vincent A. Autoimmune Disorders of the Neuromuscular Junction. Current Opinion in Pharmacology. 2009; 9: p.336-40.
3. Alshekhlee A, Miles JD, Katirji B, Preston DC, Kaminski HJ. Incidence and mortality rates of myasthenia gravis and myasthenic crisis in US hospitals. Neurology. 2009; 72:p.1548-54.
4. Tan K, Prerna A, Leo YS. Surveillance of H1N1- related neurological complications. The Lancet Neurology. 2010; 9(2): p.142-3.
5. Maricich SM, Neul JL, Lotze TE. Neurologic complications associated with influenza a in children during the 2003-2004 influenza season in Houston, Texas. Pediatrics. 2004; p.114:626-33.
6. Center for Diseases Control and Prevention (CDC). Neurologic complications associated with novel influenza A (H1N1) virus infection in children. MMWR Morb Mortal Wkly Rep. 2009; 58(28): p.773-8.
7. Martin A, Reade EP. Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clin Infect Dis. 2010; 50(8): p.50-2.
8. Meriggioli MN. Myasthenia Gravis: Immunopathogenesis, diagnosis, and management. Continuum. 2009; 15(1): p.35-62.
9. Jani-Ascadi A, Lisak RP. Myasthenic crisis: guidelines for prevention and treatment. J Neurol Sci. 2007; 261(1-2): p.127-33.
10. Perrin C, Unterborn JN, Ambrosio CD, Hill NS. Pulmonary complications of chronic neuromuscular diseases and their management. Muscle Nerve. 2004; p.29:5-27.

Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/