Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires
Keywords:
LEPTOSPIRA, SEROGROUP, WISTAR RATS.Abstract
Introduction: Leptospirosis has been experimentally investigated in Wistar rats. Although the rat resists infection, there is documentation in natural infections of the damages caused.
Objective: to demonstrate clinical-pathological damages in pregnant Wistar rats inoculated with leptospires.
Method: Twelve adult Wistar rats (270 g) maintained under appropriate conditions were used, forming three experimental groups of two rats with their controls. They were inoculated intraperitoneally with 2 ml containing 3 x 10 6 leptospires per ml of L. Ichterohaemorrhagiae, L. Canícola and L. Pomona. The variables were: ingestion of water and food, weight, behavioral changes, irritability, mucosal coloration, skin lesions, abortion, preterm birth, hemorrhages, normal birth, number of offspring, condition and weight of offspring, organ status Bleeding in the uterus or placenta. Organ cuts were made.
Results: it was observed, hyperkinesia, loss of post-inoculated pregnancy, pale mucous membranes, low appetite, low weight, hemorrhages in uterine horns, untroubled horns, bulky organs, infertility, infant and mother death, preterm birth, low birth weight , Offspring with hemorrhagic disorders. Damage to organs studied. Prevalence of circulatory disorders with vasculitis, congestion and hemorrhages in liver, heart, lung, spleen and kidney. In ovary, uterus and placenta acute and chronic inflammatory events, polycystic ovaries, yellow bodies, lymphocytic infiltration, acute, chronic, proliferative endometritis and other alterations.
Conclusions: Similar situation can occur in the pregnant woman when she acquires leptospirosis, without evaluating other damages. Injuries occur in any infected animal species.
LEPTOSPIRA; SEROGROUP; WISTAR RATS.
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References
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