Genetic factors of bronchial asthma in pediatric-aged patients in Pinar del Río

Authors

  • Odalys Orraca Castillo Hospital Pediátrico Provincial Docente Pepe Portilla de Pinar del Rio
  • Miladys Orraca Castillo Hospital Pediátrico Provincial Docente "Pepe Portilla". Pinar del Río. Cuba.
  • Roberto Lardoeyt Ferrer Centro Nacional de Genética Médica. La Habana. Cuba.
  • William Quintero Pérez Hospital Pediátrico Provincial Docente “Pepe Portilla”. Pinar del Río. Cuba.

Keywords:

BRONCHIAL ASTHMA, RHINITIS, ATOPIC DERMATITIS.

Abstract

Introduction: bronchial asthma is a disease is known by a multifactorial etiology, where genetic, immunological and environmental factors play a preponderant role.

Objective: to describe the genetic factors of bronchial asthma in pediatric-aged patients in Pinar del Río.

Method: an observational case-control study was carried out in Pinar del Río province from July 2015 to June 2016. The sample consisted of 585 patients with bronchial asthma in the pediatric-aged group and 585 controls of the same population giving rise to the cases. Pearson's nonparametric chi square test was applied, and the Odd Ratio was determined.

Results: first-degree relatives are 6.7 times more likely to be asthmatic if there is an asthmatic family member, 4.2 if they have a relative with rhinitis, and 9.2 if they have a relative with atopic dermatitis. In second-degree relatives, the probability of being asthmatic is higher in those with a history of bronchial asthma (6.3), 4.4 in relatives with rhinitis, and no significant differences for atopic dermatitis. In relation to third-degree relatives, the probability of a child being asthmatic is higher than in cases where there are no relatives affected for asthma and rhinitis (3. 9 and 4. 6 respectively), but not for atopic dermatitis (2. 4).

Conclusion: a high contribution of genetic factors to bronchial asthma in pediatric-aged patients with first, second and third degree relatives is observed.

 

 

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Author Biographies

Odalys Orraca Castillo, Hospital Pediátrico Provincial Docente Pepe Portilla de Pinar del Rio

Especialista de Primer y Segundo Grado en Inmunología. Máster en Genética Médica y en Urgencias Médicas. Profesora Auxiliar. Hospital Pediátrico Provincial Docente "Pepe Portilla". Pinar del Río. Cuba.

Miladys Orraca Castillo, Hospital Pediátrico Provincial Docente "Pepe Portilla". Pinar del Río. Cuba.

Especialista de Primer y Segundo Grado en Genética Médica. Doctora en Ciencias Biomédicas. Máster en Atención Integral al Niño. Investigadora Auxiliar. Profesora Titular. Hospital Pediátrico Provincial Docente "Pepe Portilla". Pinar del Río. Cuba.

Roberto Lardoeyt Ferrer, Centro Nacional de Genética Médica. La Habana. Cuba.

Especialista de Primer y Segundo Grado en Genética Médica. Doctor en Ciencias Biomédicas. Centro Nacional de Genética Médica. La Habana. Cuba.

William Quintero Pérez, Hospital Pediátrico Provincial Docente “Pepe Portilla”. Pinar del Río. Cuba.

Especialista de Primer Grado en Inmunología y de Segundo Grado en Medicina Intensiva. Investigador Agregado. Profesor Auxiliar. Hospital Pediátrico Provincial Docente “Pepe Portilla”. Pinar del Río. Cuba.

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Published

2017-06-01

How to Cite

1.
Orraca Castillo O, Orraca Castillo M, Lardoeyt Ferrer R, Quintero Pérez W. Genetic factors of bronchial asthma in pediatric-aged patients in Pinar del Río. Rev Ciencias Médicas [Internet]. 2017 Jun. 1 [cited 2025 Aug. 30];21(3):305-11. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/3089

Issue

Vol. 21 No. 3 (2017)

Section

ORIGINAL ARTICLES

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