Effects of calcium on body weight and blood pressure in spontaneously hypertensive rats

Authors

Keywords:

CALCIUM, BODY WEIGHT, ARTERIAL PRESSURE, RATS.

Abstract

Introduction: the role of calcium in the control of body weight and blood pressure is important because it is a promising perspective in tackling obesity and hypertension.

Objective: to evaluate the effects of calcium administration on body weight and blood pressure in spontaneously hypertensive rats (SHR).

Methods: 20 spontaneously hypertensive adult rats were included and divided into two groups: an unsupplemented hypertensive (n=10) control group and an experimental group with hypertension that was given calcium for 6 weeks orally by cannula (10,000 mcg/day). Body weight and systolic, diastolic and mean blood pressure were weekly evaluated.

Results: calcium-supplemented animals showed a reduction in body weight compared to controls, this difference being statistically significant from week 6 (student t =2.712 p=0.014). The mean blood pressure of the experimental group decreased its values compared to the controls and the reduction was statistically significant after week 3. In the systolic and diastolic blood pressures there was a statistically significant decrease in the experimental group after the third week of supplementation (t= 7,316 p=0,000) and (t=4,788 p=0,000), respectively.

Conclusions: calcium supplementation in rats spontaneously led to a reduction in body weight from week 6 onwards and reduced systolic, diastolic and mean blood pressure from week 3 onwards.

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Author Biographies

Ada Esther González Cordero, Universidad de Ciencias Médicas de Pinar del Río. Facultad de Ciencias Médicas “Dr. Ernesto Guevara de la Serna”

Especialista de Primer Grado en Fisiología Normal y Patológica, Profesor Asistente.

Yunit Hernández Rodríguez, Universidad de Ciencias Médicas de Pinar del Río. Facultad de Ciencias Médicas “Dr. Ernesto Guevara de la Serna”

Especialista de Segundo Grado en Fisiología Normal y Patológica, Profesor Auxiliar

Mileidys León García, Universidad de Ciencias Médicas de Pinar del Río. Facultad de Ciencias Médicas “Dr. Ernesto Guevara de la Serna”

Especialista de Primer Grado en Medicina General Integral. Residente de 4to año de Fisiología Normal y Patológica

Raúl Alexander Vento Pérez, Universidad de Ciencias Médicas de Pinar del Río. Facultad de Ciencias Médicas “Dr. Ernesto Guevara de la Serna”c

Especialista de Primer Grado en Medicina General Integral. Residente de 4to año de Fisiología Normal y Patológica.

Hower Díaz Lorenzo, Hospital General Docente Abel Santamaría Cuadrado

Especialista de Primer Grado en Medicina General Integral. Residente de 1er año de Cirugía General

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Published

2019-12-20

How to Cite

1.
González Cordero AE, Hernández Rodríguez Y, León García M, Vento Pérez RA, Díaz Lorenzo H. Effects of calcium on body weight and blood pressure in spontaneously hypertensive rats. Rev Ciencias Médicas [Internet]. 2019 Dec. 20 [cited 2025 Aug. 8];24(1):e4237. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/4237

Issue

Vol. 24 No. 1 (2020)

Section

ORIGINAL ARTICLES

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