Application of autologous stem cells in patients with grade IV atherosclerosis obliterans

Authors

Keywords:

ADULT STEM CELLS, ATHEROSCLEROSIS, CELL- AND TISSUE-BASED THERAPY, IMMUNOTHERAPY, ADOPTIVE.

Abstract

Introduction: peripheral arterial disease of the lower limbs affects a high percentage of the world population; with autologous stem cells obtained from peripheral blood a greater synthesis of growth factors that induce angiogenesis is achieved.

Objective: to describe the auto-transplantation of autologous stem cells obtained from peripheral blood in patients with grade IV atherosclerosis obliterans in Pinar del Rio treated during period 2009-2019.

Methods: a descriptive, longitudinal study was carried out with 296 patients with grade IV atherosclerosis obliterans during the period 2009-2019. Autologous peripheral blood stem cell concentrate was obtained. The cells were analyzed by flow cytometry, where they showed a cell viability of 99,3 %. Stem cell concentrate was injected intramuscularly with a number of cells injected of eight, six and ten. The variables studied were ankle-brachial pressure index at rest, pain-free claudication distance, pain scale assessment and amputation criteria.

Result: pain relief was observed at four weeks and increase in pain-free claudication distance. Post-treatment angiography showed collateral vessel formation. Amputation criteria were met in 95 cases (32 %) and the limb was saved in 201 patients (68 %). The procedure carried out was not associated with complications.

Conclusion: the application of autologous peripheral blood stem cells is safe and effective for the treatment of grade IV atherosclerosis obliterans.

 

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Author Biography

Antonio Jesús Díaz-Díaz, Hospital General Docente “Abel Santamaría Cuadrado”. Pinar del Río, Cuba.

Especialista de I grado en Angiología y Cirugía Vascular. Profesor Auxiliar. Master en Longevidad Satisfactoria

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Published

2022-05-15

How to Cite

1.
Díaz-Díaz AJ, Concepción-Domínguez O, Labrador-Labrador F, Martínez-Graverán R. Application of autologous stem cells in patients with grade IV atherosclerosis obliterans. Rev Ciencias Médicas [Internet]. 2022 May 15 [cited 2025 Nov. 29];26(3):e5214. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/5214

Issue

Vol. 26 No. 3 (2022)

Section

ORIGINAL ARTICLES

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