Metabolic syndrome in childhood acute lymphoblastic leukemia survivors
Keywords:
LYMPHOBLASTIC LEUKEMIA-LYMPHOMA, NEOPLASM, METABOLIC SYNDROME, ENDOCRINE SYSTEM DISEASES, RISK FACTORS.Abstract
Introduction: leukemia comprises a heterogeneous group of hematological malignancies that affect the differentiation of leukocytes in the bone marrow. The increase in disease survival is accompanied by long-term adverse effects with metabolic syndrome being one of the most important problems.
Objective: to describe the components of metabolic syndrome in survivors of childhood acute lymphoblastic leukemia.
Methods: a search was made of the main scientific articles of the last years, as well as of the printed literature that includes the subject, being selected the most relevant contents for the preparation of the article.
Results: metabolic syndrome increases its appearance in survivors of acute lymphoblastic leukemia, its main components: obesity, hypertension, dyslipidemia and insulin resistance associated or not with type 2 diabetes mellitus increase the risk of cardiovascular complications.
Conclusions: acute lymphoblastic leukemia is the most frequent clinical form of cancer in childhood. However, it is associated with metabolic syndrome in a high number of cases, which influences the quality of life of these patients and constitutes a real health problem. The early appearance of metabolic syndrome and its components among acute leukemia survivors requires early and continuous detection to identify those at risk and implement preventive measures by the multidisciplinary team of physicians specializing in pediatrics, hematology and endocrinology.
Downloads
References
1. Hernández-Martínez A, Roldán-Tabares MD, Herrera-Almanza L, Villegas-Alzate JD, Alvarez-Hdez LF, Hernández-Restrepo F, et al. Leucemia de manifestación aguda y nuevas alternativas terapéuticas. Med Int Méx[Internet]. 2019 [citado 24/11/2021]; 35(4): 553-63. Disponible en:https://doi.org/10.24245/mim.v35i4.2548
2. Rodríguez-Villamizar LA, Moreno Corzo FE, Valbuena-García AM, Uribe Pérez CJ, Brome Bohórquez MR, García Gracía HI, et al. Childhood Leukemia in Small Geographical Areas and Proximity to Industrial Sources of Air Pollutants in Three Colombian Cities. In J Environ Res Public Health[Internet]. 2020 [citado 24/11/2021];(21): 7925. Disponible en: https://www.mdpi.com/1660-4601/17/21/7925
3. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol[Internet]. 2017 [citado 24/11/2021]; 18(6): 719-31. Disponible en: https://www.sciencedirect.com/science/article/pii/S1470204517301869
4. Global Cancer Observatory International Agency for Research on Cancer. World Cancer Today[Internet]; 2018 [citado 22/05/2020]. Disponible en: https://gco.iarc.fr/today/home
5. Equipo de redactores y equipo de editores médicos de la Sociedad Americana contra el Cáncer. Estadísticas importantes sobre la leucemia en niños[Internet]. 2019 [citado 24/11/2021]; 2019 [citado 02/05/2019]. Disponible en: https://www.cancer.org/es/cancer/leucemia-en-ninos/acerca/estadisticasclave.html
6. Jeha S, Pui ChH. Clinical manifestations and treatment of childhood acute lymphoblastic leukemia. En: Hoffman R. Hematology: Basic Principles and Practice. 7th ed. Canada: Elsevier S.A[Internet]; 2017[citado 24/11/2021]. Disponible en: https://www.elsevier.com/books/hematology/9780323357623
7. Machín SA, Leblanch CC, García MB, Escalona Y, Alvarez I,Plá MJ, et al. Caracterización de las leucemias en niños en Cuba (2006-2015). Revista Cubana de Hematología. [Internet]. 2020 [citado 24/11/2021]; 36(1): e1103. Disponible en http://www.revhematologia.sld.cu/index.php/hih/article/view/1103
8. Pluimakers VG, van Waas M, Neggers SJCMM, van den Heuvel-Eibrink MM. Metabolic syndrome as cardiovascular risk factor in childhood cancer survivors. Critical reviews in oncology/hematology[Internet]. 2019 [citado 24/11/2021]; 133: 129-141. Disponible en:https://www.sciencedirect.com/science/article/abs/pii/S104084281830204X
9. Oudin C, Berbis J, Bertrand Y, Vercasson C, Thomas F, Chastagner P, et al. Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors' cohort: a comparison with controls from the French population. Haematologica. [Internet]. 2018 [citado 24/11/2021]; 103(4): 645-54. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865433/
10. Yu C. Endocrine Consequences of Childhood Cancer Therapy and Transition Considerations. Pediatr Ann[Internet]. 2019 [citado 24/11/2021]; 48(8): 326-32. Disponible en:https://pubmed.ncbi.nlm.nih.gov/31426101/
11. Casano Sancho P. Endocrine sequelae in childhood cancer survivors. Endocrinol Diabetes Nutr[Internet]. 2017 [citado 24/11/2021]; 64(9): 498-505. Disponible en: https://doi.org/10.1016/j.endinu.2017.06.006
12. Saklayen MG. The Global Epidemic of Metabolic Syndrome. Curr Hypertens Rep[Internet]. 2018 [citado 24/11/2021]; 20(2): 1-8. Disponible en: https://doi.org/10.1007/s11906-018-0812-z
13. GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, et al. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med[Internet]. 2017 [citado 24/11/2021]; 377(1): 13-27. Disponible en: https://doi.org/10.1056/NEJMoa1614362
14. Ogurtsova K, Fernandes JD, Huang Y, et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice [Internet]. 2017[citado 24/11/2021]; 128: 40–50. Disponible en: https://doi.org/10.1016/j.diabres.2017.03.024
15. Bussler S, Penke M, Flemming G, Elhassan YS, Kratzsch J, Sergeyev E, et al. Novel Insights in the Metabolic Syndrome in Childhood and Adolescence. Horm Res Paediatr[Internet]. 2017 [citado 24/11/2021]; 88(3-4): 181-193. Disponible en: https://doi.org/10.1159/000479510
16. Weihe P, Weihrauch-Blüher S. Metabolic Syndrome in Children and Adolescents: Diagnostic Criteria, Therapeutic Options and Perspectives. Curr Obes Rep[Internet]. 2019 [citado 24/11/2021]; 8(4): 472-479. Disponible en: https://doi.org/10.1007/s13679-019-00357-x
17. Reisinger C, Nkeh-Chungag BN, Fredriksen PM, Goswami N. The prevalence of pediatric metabolic syndrome—a critical look on the discrepancies between definitions and its clinical importance. Int J Obes (Lond) [Internet]. 2021 [citado 24/11/2021]; 45(1): 12–24. Disponible en: https://doi.org/10.1038/s41366-020-00713-1
18. Zafar U, Khaliq S, Ahmad HU, Manzoor S, LoneKP. Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links. Hormones (Athens) [Internet]. 2018 [citado 24/11/2021]; 17(3): 299-313. Disponible en: https://doi.org/10.1007/s42000-018-0051-3
19. Chueh H W, Yoo J H. Metabolic syndrome induced by anticancer treatment in childhood cancer survivors. Ann Pediatr Endocrinol Metab[Internet]. 2017 [citado 24/11/2021]; 22(2): 82-9. Disponible en: https://doi.org/10.6065/apem.2017.22.2.82
20. Bielorai B, Pinhas-Hamiel O. Type 2 Diabetes Mellitus, the Metabolic Syndrome, and Its Components in Adult Survivors of Acute Lymphoblastic Leukemia and Hematopoietic Stem Cell Transplantations. Curr Diab Rep[Internet]. 2018 [citado 24/11/2021]; 18(6): 32. Disponible en: https://doi.org/10.1007/s11892-018-0998-0
21. Caubet Fernandez M, Drouin S, Samoilenko M, Morel S, Krajinovic M, Laverdière C, et al. A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study. BMC Med Res Methodol [Internet]. 2019 [citado 02/05/2019]; 19(1): 100. Disponible en: https://doi.org/10.1186/s12874-019-0725-9
22. Morel S, Léveillé P, Samoilenko M, Franco A, England J, Malaquin N, et al. Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia. Sci Rep [Internet]. 2020 Dec [citado 02/05/2019]; 10(1): 21507. Disponible en: https://doi.org/10.1038/s41598-020-78493-x
23. Barbosa-Cortés L., López-Alarcón M., Mejía-Aranguré JM, Klünder-Klünder M, Rodríguez-Zepeda MC, Rivera-Márquez H, et al. Adipocinas, resistencia a la insulina y adiposidad como predictores del síndrome metabólico en niños sobrevivientes de linfoma y leucemia linfoblástica aguda de un país en desarrollo. BMC Cancer [Internet]. 2017 [citado 02/05/2019]; 17: 125. Disponibe en: https://doi.org/10.1186/s12885-017-3097-8
24. Paviglianiti A. Endocrine and Metabolic Disorders after Hematopoietic Cell Transplantation. Turk J Hematol[Internet]. 2020 [citado 24/11/2021]; 37(2):111-15. Disponible en: https://doi.org/10.4274/tjh.galenos.2019.2019.0248.
25. Friedman DN, Tonorezos ES, Cohen P. Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer. Horm Res Paediatr[Internet]. 2019 [citado 24/11/2021];.;91(2):118-27. Disponible en: https://doi.org/10.1159/000495698
26. Morel S, Leahy J, Fournier M, Lamarche B, Garofalo C, Grimard G, et al. Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors. J Lipid Res[Internet]. 2017 [citado 24/11/2021];58(5): 982-93. Disponible en: https://doi.org/10.1194/jlr.M072207
27. England J, Drouin S, Beaulieu P, St-Onge P, Krajinovic M, Laverdière C, et al. Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. BMC Cancer [Internet]. 2017 [acceso 02/05/2019]; 17(1): 751. Disponible en: https://doi.org/10.1186/s12885-017-3722-6
28. Bérard S, Morel S, Teasdale E, Shivappa N, Hebert JR, Laverdière C, et al. Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia. Nutrients[Internet]. 2020 Jul [citado 24/11/2021]; 12(7): 2137. Disponible en: https://doi.org/10.3390/nu12072137
29.Howell CR, Wilson CL, Ehrhardt MJ, Partin RE, Kaste SC, Lanctot JQ, Pui CH, Robison LL, Hudson MM, Ness KK. Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study. Cancer[Internet]. 2018 Mar [citado 24/11/2021]; 124(5): 1036-1043. Disponible en: https://doi.org/10.1002/cncr.31162
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
