Platelet rich fibrin and its use in dentistry
Keywords:
PLATELET-RICH FIBRIN, PERIODONTICS, ENDODONTICS.Abstract
Introduction: Platelet-rich fibrin (PRF) is considered a regenerative material that possesses a large amount of growth factors, leukocytes, platelets and cytokines that are required in healing processes. In dentistry, it is a growing trend due to its versatility, especially in oral and maxillofacial surgery, oral implantology and periodontics.
Methods: The methodology used was PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analysis Protocols, where the search criteria were met according to Cochrane standards for systematic reviews. In addition, the Perish or Perish tool was used for data extraction, in order to carry out this search for articles related to the object of study.
Development: platelet-rich fibrin is obtained by centrifugation of the patient's own blood without artificial biochemical modification. Among its main properties are the stimulation of osteoblast differentiation and proliferation, stimulation of angiogenesis and mitogenic effect. It has a wide use in the field of dentistry. In periodontics and oral implantology it has multiple applications, to treat gingival recessions, in maxillary sinus floor elevation, increases the effect of coagulation/tissue regeneration at the surgical site by means of a natural clot that accelerates the healing of soft and hard tissues.
Conclusions: It is concluded that the benefits of FRP in the recovery of patients, therefore, the feasibility of its use in different procedures, whether they are periodontics, endodontics, surgery or easy harmonization, is evidenced.
Downloads
References
1. Toffler M, Toscano N, Holtzclaw D, Corso M, Do-han Ehrenfest D. Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Im-plant Adv Clin Dent [Internet]. 2009 [citado 11/11/2022]; 1(6): 21-30. Disponible en: https://www.scienceopen.com/document?vid=5bd238ed-da6e-42d6-8089-ca62e8946efb
2. Meza-Mauricio EJ, Lecca-Rojas MP, Correa-Quispilaya E, Ríos-Villasis K. Fibrina rica en plaquetas y su aplicación en periodoncia: revisión de literatura. Revista Estomatológica Herediana [Internet]. octubre de 2014 [citado 11/11/2022]; 24(4): 287-93. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_abstract&pid=S1019-43552014000400011&lng=es&nrm=iso&tlng=es
3. Gupta V, Bains VK, Singh GP, Mathur A, Bains R. Regenerative Potential of Platelet Rich Fibrin in Dentistry: Literature Review. AJOHAS [Internet]. 2011 [citado 11/11/2022]; 1(1): 22-28. Disponible en: https://sdcindia.ac.in/document/docsafe/202204071116725714.pdf
4. Mosesson MW, Siebenlist KR, Meh DA. The structure and biological features of fibrinogen and fibrin. Ann N Y Acad Sci [Internet]. 2001 [citado 21/11/2022]; 936: 11-30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11460466/
5. Gassling VLW, Açil Y, Springer IN, Hubert N, Wiltfang J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. julio de 2009 [citado 11/11/2022]; 108(1): 48-55. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19451011/
6. Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res [Internet]. 2008 [citado 12/11/2022]; 19(1): 42-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18245923/
7. Yáñez Ocampo BR, Marín González MG. Tratamiento de periodontitis agresiva localizada con plasma rico en plaquetas y aloinjerto óseo: Un caso clínico. Revista odontológica mexicana [Internet]. junio de 2015 [citado 10/11/2022]; 19(2): 106-14. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1870-199X2015000200007&lng=es&nrm=iso&tlng=es
8. Hernández I, Rossani G, Alcolea JM, Castro-Sierra R, Pérez Soto W, Trelles MA. Utilidad práctica de la fibrina autóloga en medicina reparadora y cirugía plástica. Cirugía Plástica Ibero-Latinoamericana [Internet]. septiembre de 2014 [citado 10/11/2022]; 40(3): 345-57. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0376-78922014000300016&lng=es&nrm=iso&tlng=es
9. Lobatón A, Mantilla A, Felzani R, Suarez D, Gonzalez A. Efecto de la fibrina rica en plaquetas para la cicatrización de tejidos blandos post - exodoncia de terceros molares inferiores retenidos. Acta Odontológica Venezolana [Internet]. 2015 [citado 11/11/2022]; 53(3). Disponible en: https://www.actaodontologica.com/ediciones/2015/3/art-11/
10. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. marzo de 2006 [citado 10/11/2022]; 101(3): e37-44. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16504849/
11. Kim SG, Zhou J, Solomon C, Zheng Y, Suzuki T, Chen M, et al. Effects of growth factors on dental stem/progenitor cells. Dent Clin North Am [Internet]. julio de 2012 [citado 12/11/2022]; 56(3): 563-75. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22835538/
12. Xiang X, Shi P, Zhang P, Shen J, Kang J. Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis. BMC Oral Health [Internet]. 25 de julio de 2019 [citado 21/11/2022]; 19(1):163. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31345203/
13. Du Toit J, Siebold A, Dreyer A, Gluckman H. Choukroun Platelet-Rich Fibrin as an Autogenous Graft Biomaterial in Preimplant Surgery: Results of a Preliminary Randomized, Human Histomorphometric, Split-Mouth Study. Int J Periodontics Restorative Dent [Internet]. 2016 [citado 11/11/2022]; 36 Suppl: s75-86. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27031636/
14 Herrera A, Aguirre NS. La belleza orofacial inteligente: una reflexión epistémica desde el cliente odontológico venezolano. CIENCIA ergo-sum [Internet]. 18 de mayo de 2022 [citado 11/11/2022]; 29(2). Disponible en: https://cienciaergosum.uaemex.mx/article/view/15360
15. Urrútia G, Bonfill X. Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica [Internet]. 2010 [citado 11/11/2022]; 135(11): 507-11. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=3300057
16. Giraldo TR, Rojas HS. Endodoncia regenerativa: utilización de fibrina rica en plaquetas autóloga en dientes permanentes vitales con patología pulpar. Revisión narrativa de la literatura*. Acta Odontológica Colombiana [Internet]. 1 de enero de 2014 [citado 12/11/2022]; 4(1): 91-112. Disponible en: https://revistas.unal.edu.co/index.php/actaodontocol/article/view/44608
17. López-Pagán E, Pascual-Serna AC. Fibrina rica en plaquetas en la cicatrización de los tejidos periodontales. Odontología Sanmarquina [Internet]. 21 de febrero de 2020 [citado 11/11/2022]; 23(1): 43-50. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/odont/article/view/17506
18. Vaca Bohórquez MG. Uso de fibrina rica en plaquetas para mejorar la cicatrización en cirugía aplicada a la Odontología [Tesis]. Universidad Católica de Santiago de Guayaquil; 8 de marzo de 2021 [citado 12/11/2022]. Disponible en: http://repositorio.ucsg.edu.ec/handle/3317/16176
19. Jang ES, Park JW, Kweon H, Lee KG, Kang SW, Baek DH, et al. Restoration of peri-implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. junio de 2010 [citado 13/11/2022]; 109(6): 831-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20163973/
20. Areewong K, Chantaramungkorn M, Khongkhunthian P. Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: A randomized controlled trial. Clin Implant Dent Relat Res [Internet]. diciembre de 2019 [citado 14/11/2022]; 21(6): 1156-63. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31647177/
21. Ustaoğlu G, Göller Bulut D, Gümüş KÇ. Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction. J Stomatol Oral Maxillofac Surg [Internet]. noviembre de 2020 [citado 14/11/2022]; 121(5): 539-44. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31526905/
22. Afat IM, Akdoğan ET, Gönül O. Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on early soft tissue healing after surgical extraction of impacted mandibular third molars: A prospective clinical study. J Craniomaxillofac Surg [Internet]. febrero de 2019 [citado 12/11/2022]; 47(2): 280-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30579747/
23. Dutta SR, Passi D, Singh P, Sharma S, Singh M, Srivastava D. A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing. Natl J Maxillofac Surg [Internet]. 2016 [citado 15/11/2022]; 7(1): 45-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28163478/
24. Sharma A, Ingole S, Deshpande M, Ranadive P, Sharma S, Kazi N, et al. Influence of platelet-rich fibrin on wound healing and bone regeneration after tooth extraction: A clinical and radiographic study. J Oral Biol Craniofac Res [Internet]. 2020 [citado 12/11/2022]; 10(4): 385-90. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393389/
25. Diana C, Mohanty S, Chaudhary Z, Kumari S, Dabas J, Bodh R. Does platelet-rich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial. Int J Oral Maxillofac Surg [Internet]. septiembre de 2018 [citado 11/11/2022]; 47(9): 1178-88. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29402513/
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/