Therapeutic options in trigeminal neuralgia

Authors

Keywords:

TRIGEMINAL NEURALGIA, TRIGEMINAL NERVE, THERAPEUTICS, NERVE GROWTH FACTORS, THERAPEUTIC USES.

Abstract

Introduction: the cranial nerve V is responsible for sensation in the face, including the mouth. Trigeminal neuralgia causes sudden intense pain in the face, which can be shooting, shooting or sharp.

Objective: to describe the therapeutic options in trigeminal neuralgia.

Methods: a literature review was performed by searching the Scopus and PubMed/MedLine databases for information. Clinical trials and meta-analyses published in the last five years were included.

Results: both nerve growth factor and brain-derived neurotrophic factor can cause and treat pain. The occurrence of pain is a biological self-defense mechanism; during treatment, the therapeutic effect of neurotrophic factors can be maintained and pain can be reduced.

Conclusions: based on the results, the classification of trigeminal neuralgia now includes two scientifically based subgroups, idiopathic and classic trigeminal neuralgia. A diagnostic evaluation is necessary in order to offer an adequate treatment.

Downloads

Download data is not yet available.

References

1. Cruccu G, Di Stefano G, Truini A. Trigeminal Neuralgia. N Engl J Med [Internet]. 2020 [06/06/2023]; 383: 754–62. Disponible en: http://www.nejm.org/doi/10.1056/NEJMra1914484

2. Boto GR. Neuralgia del trigémino. Neurocirugia [Internet]. 2010 [06/06/2023]; 21(5): 361–72. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1130147310700865

3. Castelli N, Innocenti N, Ferroli P, Saladino A, Broggi G, Tramacere I, et al. Microvascular decompression for trigeminal neuralgia: a single-center experience with 516 cases, including 32 patients with multiple sclerosis. Acta Neurochir (Wien) [Internet]. 2023 [06/06/2023]; 165: 3887–93. Disponible en: https://link.springer.com/10.1007/s00701-023-05872-4

4. Li S, Liao C, Cheng G, Wu Y, Zhang W. Proximal trigeminal nerve atrophy is associated with favourable outcomes and persistent facial numbness following percutaneous balloon compression for primary trigeminal neuralgia. Acta Neurochir (Wien) [Internet]. 2023 [06/06/2023]; 165: 3867–76. Disponible en: https://link.springer.com/10.1007/s00701-023-05849-3

5. Kimura T, Ichi S. How I do it: re-do surgery for recurrent trigeminal neuralgia. Acta Neurochir (Wien) [Internet]. 2022 [06/06/2023]; 164: 3249–52. Disponible en: https://link.springer.com/10.1007/s00701-022-05390-9

6. Singhota S, Tchantchaleishvili N, Wu J, Zrinzo L, Thorne L, Akram H, et al. Long term evaluation of a multidisciplinary trigeminal neuralgia service. J Headache Pain [Internet]. 2022 [06/06/2023]; 23: 114. Disponible en: https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01489-7

7. Lambru G, Stubberud A, Rantell K, Lagrata S, Tronvik E, Matharu MS. Medical treatment of SUNCT and SUNA: a prospective open-label study including single-arm meta-analysis. J Neurol Neurosurg Psychiatry [Internet]. 2021 [06/06/2023]; 92(3): 233–41. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33361408/

8. Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia – diagnosis and treatment. Cephalalgia [Internet]. 2017 [06/06/2023]; 37(7):648–57. Disponible en: http://journals.sagepub.com/doi/10.1177/0333102416687280

9. Maarbjerg S, Benoliel R. The changing face of trigeminal neuralgia—A narrative review. Headache J Head Face Pain [Internet]. 2021 [06/06/2023]; 61(6): 817–37. Disponible en: https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14144

10. Wu J, Xiao Y, Chen B, Zhang R, Dai M, Zhang Y. Efficacy and safety of microvascular decompression versus percutaneous balloon compression in the treatment of trigeminal neuralgia: a systematic review and meta-analysis. Ann Palliat Med [Internet]. 2022 [06/06/2023]; 11(4): 1391–400. Disponible en: https://apm.amegroups.org/article/view/93435/html

11. Feng F, Xu Q, Wu Q, Jia C, Cai Y. Radiofrequency Thermocoagulation Through the Foramen Rotundum Versus the Foramen Ovale for V2 Primary Trigeminal Neuralgia: A Systematic Review and Meta-analysis. Pain Physician [Internet]. 2023 [06/06/2023]; 26(6): E627–33. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/37847916

12. Liao J-Y, Zhou T-H, Chen B-K, Liu Z-X. Schwann cells and trigeminal neuralgia. Mol Pain [Internet]. 2020 [06/06/2023]; 16: 174480692096380. Disponible en: http://journals.sagepub.com/doi/10.1177/1744806920963809

13. Yan C, Zhang Q, Liu C, Yang J, Bian H, Zhu J, et al. Efficacy and safety of radiofrequency in the treatment of trigeminal neuralgia: a systematic review and meta-analysis. Acta Neurol Belg [Internet]. 2022 [06/06/2023]; 122(4):1019–30. Disponible en: https://link.springer.com/10.1007/s13760-021-01654-w

14. Yu X, Lv W, Liu X, Kang X, Zhang L. Abnormal activation of brain regions in idiopathic trigeminal neuralgia patients by fMRI: An activation likelihood estimation meta-analysis. Clin Neurol Neurosurg [Internet]. 2023 [06/06/2023]; 228: 107710. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0303846723001269

15. Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, et al. Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia. Lancet Neurol [Internet]. 2020 [06/06/2023]; 19(9):784–96. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1474442220302337

16. Wang Z, Wang Z, Li K, Su X, Du C, Tian Y. Radiofrequency thermocoagulation for the treatment of trigeminal neuralgia. Exp Ther Med [Internet]. 2022 [06/06/2023]; 23(1): 17. Disponible en: http://www.spandidos-publications.com/10.3892/etm.2021.10939

17. Zeng C, Zhang C, Li Y-H, Feng X, Zhang M-J, Xiao R-H, et al. Recent Advances of Magnetic Resonance Neuroimaging in Trigeminal Neuralgia. Curr Pain Headache Rep [Internet]. 2021 [06/06/2023]; 25(6): 37. Disponible en: https://link.springer.com/10.1007/s11916-021-00957-0

Downloads

Published

2023-12-28

How to Cite

1.
Pinta-Riofrio MD, Checa-Huilcatoma SA, Sánchez-Sánchez JE. Therapeutic options in trigeminal neuralgia. Rev Ciencias Médicas [Internet]. 2023 Dec. 28 [cited 2025 Sep. 18];27:e6287. Available from: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/6287

Issue

Vol. 27 (2023): (Sistema de Publicación Continua)

Section

REVIEW ARTICLES

License

Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.

Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/