Anti-ulcer properties of Aloe Vera in the treatment of gastric ulcers
Keywords:
ALOE VERA, STOMACH ULCER, PHYTOCHEMICALS.Abstract
Introduction: the knowledge of the properties of Aloe Vera allows people to use its phytochemical properties, not only in gastric ulcer, but in a diversity of pathologies that require antioxidant, regenerative, antisecretory and anti-inflammatory power.
Objective: to describe the phytochemical compounds present in aloe vera for the treatment of gastric ulcer and to analyze the anti-ulcer properties of aloe vera gel.
Methods: a narrative bibliographic review was carried out where a total of 26 documents extracted from the search in databases such as Pubmed, Scielo, Redalyc, Scopus were analyzed. Scientific articles with inclusion criteria such as phytochemical properties of aloe vera, pathophysiology of gastric ulcer, clinical studies of aloe vera in animals and humans, socioeconomic data of Ecuador and books were used as sources of information.
Development: pathologies of gastric origin are present in more than half of the world's population, where the factors that affect this problem are gastric ulcers. Aloe vera gel has a cytoprotective effect on the gastric mucosa due to the presence of polysaccharides, minerals, proteins, lipids and vitamins of aloe that stimulate the formation of cyclooxygenases and prostaglandins that protect the intestinal mucosa.
Conclusions: aloe vera, due to its rich vitamin C content, acts by reducing cell oxidation, increasing protection against oxidizing agents, which reduces oxidative stress present in the gastric lesion process.
Downloads
References
1. WGO. Directrices mundiales de la WGO Helicobacter pylori [Internet]. WGO; 2021 [citado 12/07/2023]. Disponible en: https://www.worldgastroenterology.org/UserFiles/file/guidelines/helicobacter-pylori-spanish-2021.pdf
2. ENEMDU. Encuesta Nacional de Empleo, Desempleo y Subempleo [Internet]. ENEMDU; 2022 [citado 02/072023]. Disponible en: https://www.ecuadorencifras.gob.ec/enemdu-anual-2022/
3. Bescós MM, Pontes AR, Muñoz RC, Margalejo AA, Roca JM. Helicobacter pylori. Tratamiento. FMC - Form Médica Contin en Atención Primaria [Internet]. 2023 [citado 10/07/2023]; 30(6): 317–21. Disponible en: https://www.sciencedirect.com/science/article/pii/S1134207223000993
4. Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM. Diagnosis and Treatment of Peptic Ulcer Disease. Am J Med [Internet]. 2019 [citado 21/06/2023]; 132(4): 447–56. Disponible en: https://www.sciencedirect.com/science/article/pii/S000293431930004X
5. da Costa GD, Defilippi GC. Helicobacter pylori: qué debemos saber en el año 2018. Revisión de la evidencia y nuevas recomendaciones de tratamiento TT - Helicobacter pylori: what should we know in the year 2018. Review of the evidence and new treatment recommendations. Rev Hosp Clin Univ Chile [Internet]. 2019 [citado 18/06/2023]; 30(1): 3–11. Disponible en: https://www.redclinica.cl/Portals/0/Users/014/14/14/1555.pdf
6. Rodríguez Ramos FJ, Acela María Boffill Corrales D, Rodríguez Soria AL, Losada Guerra LJ, Socías Barrientos ZD. Factores de riesgo asociados a la gastritis aguda o crónicaen adultos de un hospital ecuatoriano. Medisan [Internet]. 2019 [citado 03/07/2023]; 23(3): 424–34. Disponible en: http://scielo.sld.cu/pdf/san/v23n3/1029-3019-san-23-03-424.pdf
7. Molero Paredes T, Viloria M. Características morfológicas y producción de aloína de plantas poliploides de Aloe vera (L.) Burm. F. (Asphodelaceae). Bioagro [Internet]. 2020 [citado 22/07/2023]; 33(1): 41–50. Disponible en: https://dialnet.unirioja.es/descarga/articulo/7903867.pdf
8. Sousa HMP, Dias JO de SB, Queiroz PVA de, Sá WR de S, Sousa WL de A, Sousa IJO. Aplicação da Aloe vera l. no tratamento de gastrite. Res Soc Dev [Internet]. 2022 [citado 01/082023]; 11(7): e53011730316. Disponible en: https://rsdjournal.org/index.php/rsd/article/view/30316/26110
9. Barros JV de M, Nery MDM, Coutinho BN, Silva HF de L, Berenguer MIR, Do Vale CC, et al. Aplicação da Aloe vera no tratamento da gastrite e benefícios do seu uso em disfunções gastrointestinais: Uma revisão de literatura / Application of Aloe vera in the treatment of gastritis and benefits of its use in gastrointestinal disorders: A literatur. Brazilian J Dev [Internet]. 2021 [citado 30/07/2023]; 7(4): 42789–95. Disponible en: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/28964/22878
10. Quintero Díaz M, Behar Hasday R, García Lima CE, Pupo Olivero D, Hernández Domínguez M, Díaz Elías J, et al. Aloe gel viscoso® en el tratamiento de pacientes con úlcera duodenal y Helicobacter pylori positivo. Rev Cuba Plantas Med [Internet]. 2009 [citado 06/07/2023]; 14(4): 0. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1028-47962009000400002&script=sci_abstract
11. Gonzales Llontop L, Chotón Calvo M, Chico Ruiz J. Efecto histoprotector de Aloe vera L. “sábila” en ratas con daño gástrico provocado por indometacina. Rev Alfa [Internet]. 2021 [citado 09/06/2023]; 5(14): 262–73. Disponible en: http://www.scielo.org.bo/pdf/arca/v5n14/2664-0902-arca-5-14-262.pdf
12. Molina-ordóñez RAJ, Morán F, Moreno-lozano J. Efecto protector del Aloe vera (sábila) en lesiones gástricas inducidas con etanol en ratas. Protective effect of Aloe vera in injuries gastric. Cimel [Internet]. 2007 [coitado 19/07/2023]; 12(2): 71–5. Disponible en: https://sisbib.unmsm.edu.pe/bvrevistas/cimel/v12_n2/pdf/a07v12n2.pdf
13. Aparicio Salcedo SV, Carranza Aldana BS, Chávez Salas SA, Quispe Tinco LS, Palomino Zevallos CA, Peralta Medina ANPM, et al. Pharmacological efficacy of Aloe vera in wound healing: a narrative review. Rev la Fac Med Humana [Internet]. 2023 [citado 20/07/2023]; 23(1): 110–20. Disponible en: https://revistas.urp.edu.pe/index.php/RFMH/article/view/4341/7412
14. Barbosa Filho JS, Oliveira Filho JS de, Gomes EG de O, Moraes MSB de, Pessôa Filho AT, Oliveira EJD, et al. Propriedades farmacológicas da Aloe vera: uma revisão integrativa. Res Soc Dev [Internet]. 2022 [citado 12/07/2023]; 11(3): e6311326062. Disponible en: https://rsdjournal.org/index.php/rsd/article/download/26062/22987/307374
15. Kweon DY, Song HJ, Kim JE, Jin YJ, Roh YJ, Seol A, et al. Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium. Curr Issues Mol Biol [Internet]. 2023 [citado 07/08/2023]; 45(2): 1483–99. Disponible en: https://www.mdpi.com/1467-3045/45/2/96
16. Ahmad M, Ali SW, Hameed A, Amir M, Ashraf J, Afzal MI, et al. Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model. Food Sci Technol [Internet]. 2023 [citado 02/07/2023]; 43: e110321. Disponible en: https://www.scielo.br/j/cta/a/8jRZ483bCdjymWPrxT3WP5x/
17. Yusuf S, Agunu A, Diana M. The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. J Ethnopharmacol [Internet]. 2004 [citado 20/06/2023]; 93(1): 33–7. Disponible en: https://www.sciencedirect.com/science/article/pii/S0378874104001199
18. Romero C, Viteri L, Campos J, Larrea F. Factores epidemiológicos asociados a la gastritis aguda por Helicobacter pylorien pacientes atendidos en un servicio de gastroenterología. Rev Científica Mundo la Investig y el Conoc [Internet]. 2018 [citado 06/08/2023]; 2(3): 694–704. Disponible en: https://www.recimundo.com/index.php/es/article/view/328/pdf
19. Andrés B, Antepara V, José M, Franco S, Néstor, Espinosa Sánchez R, et al. Hemorragia digestiva alta por ulcera péptica o duodenal. Recimundo [Internet]. 2019 [citado 18/07/2023]; 3(2): 594–614. Disponible en: https://www.recimundo.com/index.php/es/article/view/482/686%0A
20. Altaf S, Abbas RZ, Akhtar T, Siddique F, Mahmood MS, Khan MK, et al. Antioxidant rich medicinal plants as a potential candidate to treat gastric ulcer. Bol Latinoam y del Caribe Plantas Med y Aromat [Internet]. 2023 [citado 04/08/2023]; 22(5): 560–80. Disponible en: https://blacpma.ms-editions.cl/index.php/blacpma/article/view/359
21. Costa ATA, Holanda JK da N, Souza LDG de, Custódio LLP, Rodas L de A, Oliveira Filho AA de. Babosa (Aloe Vera) e camomila (Matricaria chamomilla) no tratamento da estomatite aftosa recorrente. Arch Heal Investig [Internet]. 2020 [citado 23/07/2023]; 8(11): 751–5. Disponible en: https://www.archhealthinvestigation.com.br/ArcHI/article/view/4661/pdf
22. Shi G, Jiang H, Feng J, Zheng X, Zhang D, Jiang C, et al. Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier. J Ethnopharmacol [Internet]. 2021 [coitado 26/06/2023]; 279: 114108. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33839199/
23. Rodríguez IR, Martínez YGR, Martínez AI. Evolución del tratamiento de la Úlcera péptica duodenal. Rev Habanera Ciencias Medicas [Internet]. 2020 [citado 11/07/2023]; 20(4): e3293. Disponible en: https://www.redalyc.org/journal/1804/180468227004/180468227004.pdf
24. Andrade Júnior FP de, Aciole IHM, Souza AK de O, Alves TWB, Souza JBP de. Uso de babosa (aloe vera l.) como pró – cicatrizante em diferentes formas farmacêuticas: uma revisão integrativa. Rev Ciências Médicas e Biológicas [Internet]. 2020 [citado 10/07/2023]; 19(2): 347-352. Disponible en: https://periodicos.ufba.br/index.php/cmbio/article/view/31939/23205
25. Mota-Ituarte M, Pedroza-Sandoval A, Minjares-Fuentes R, Trejo-Calzada R, Zegbe JA, Quezada-Rivera JJ. Water deficit and salinity modify some morphometric, physiological, and productive attributes of Aloe vera (L.). Bot Sci [Internet]. 2023 [citado 25/07/2023]; 101(2): 463–75. Disponible en: https://www.scielo.org.mx/pdf/bs/v101n2/2007-4476-bs-101-02-463.pdf
26. Artunduaga Antury KL, Vargas Rojas DA, Barrera Bermeo ÓM. Conservación de las propiedades nutraceúticas del Aloe Vera (Aloe Barbadensis Miller), mediante técnicas de secado. Ing y Región [Internet]. 2021 [citado 16/06/2023]; 25: 6–21. Disponible en: https://journalusco.edu.co/index.php/iregion/article/view/2818/4074
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
