Relationship of periodontitis and Covid-19 in patients suffering from systemic comorbidities
Keywords:
PERIODONTITIS, SYSTEMIC DISEASE, COMORBIDITY, CARDIOVASCULAR DISEASES, OBESITY.Abstract
Introduction: periodontal disease is an infectious and inflammatory condition, and its development and severity involves local factors such as biofilm and systemic factors specific to the host.
Objective: to argue the relationship between periodontal disease and complications in patients with comorbidities and COVID-19.
Methods: a narrative literature review was carried out using the Google Scholar search engine in databases such as Clinicalkey, Pubmed, Scielo, Medigraphic. Inclusion criteria were: studies from the last five years, epidemiological studies, observational studies in patients. Exclusion criteria: studies older than five years, monographs, literature reviews, studies not performed on humans.
Results: the literature consulted indicates that there is a direct relationship between COVID-19 and the severity of periodontal disease in patients with comorbidities such as diabetes, hypertension or cardiovascular disease, and obesity, among others. During the course of the pandemic, there were significant findings of oral manifestations in patients with COVID-19, and it also plays an important role in virus entry and transmission.
Conclusions: oral health plays an important role in the prevention and eventual complications due to COVID-19, taking into account the systemic risk factors that could lead to aggravate the disease.
Downloads
References
1. Hernández Vigueras S, Aquino Martínez R. Potencial Rol de la Periodontitis en la Severidad del covid-19. Int. J. Odontostomat [Internet]. 2021 [Citado 20/06/2024]; 15(2): 335-341. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2021000200335
2. Alves Costa C, Serafim Vilela AC, Aparecida Oliveira S, Dias Gomes T, Costa Andrade A, Rodrigues Leles C, et al. Poor oral health status and adverse COVID-19 outcomes: A preliminary study in hospitalized patients. American Academy of Periodontology [Internet]. 2022 [Citado 20/06/2024]; 93(12): 1889-1901. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35294780/
3. García-Hernández M, Jiménez-Villegas J, Santos-Oliva S, Monjáras-Ávila J. Principales factores agravantes de enfermedad periodontal y SARS-CoV-2. Educación y Salud Boletín Científico Instituto de Ciencias de la Salud. Universidad Autónoma del Estado de Hidalgo [Internet]. 2021 [Citado 20/06/2024]; 10(19): 110-115. Disponible en: https://repository.uaeh.edu.mx/revistas/index.php/ICSA/article/view/8194/8419
4. Drozdzik A. Covid-19 and SARS-CoV-2 infection in Periodontolgy: A narrative review. Journal Periodontology [Internet]. 2022 [Citado 20/06/2024]; 57(5): 933-941. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1111/jre.13034
5. Marouf N, Cai W, Said KN, Daas H, Diab H, Rao Chinta V, et al. Association between periodontitis and severity of COVID-19 infection: A case–control. Journal of Clinical Periodontology [Internet]. 2021 [Citado 20/06/2024]; 48(4): 483-491. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33527378/
6. Anand S, Jadhav P, Kamath KP, Kumar SR, Anil S. A case-control study on the association between Periodontitis and coronavirus disease (covid-19). American Academy of Periodontology [Internet]. 2022 [Citado 20/06/2024]; 93(4): 584-590. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34347879/
7. Gardelis , Zekeridou , Suh , Terrier L, Stavropoulos , Giannopoulou. A pilot clinical and radiographic study on the association between periodontitis and serious COVID‐19 infection. Clinical and Experimental Dental Research [Internet]. 2022 [Citado 20/06/2024]; 8(5): 1021-1027. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35932180/
8. Brandini D, Takamiya A, Thakkar P, Schaller S, Rahat R, Naqvi A. Covid‐19 and oral diseases: Crosstalk, synergy or Asociation? Rev Med Virol [Internet]. 2021 [Citado 20/06/2024]; 31(6): e2226. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33646645/
9. Glavina A, Biočina-Lukenda D, Mravak-Stipeti M, Markeljevi J. Oral symptoms and lesions in SARS-CoV-2-positive patient. Oral Diseases [Internet]. 2022 [Citado 20/06/2024]; 28 (Suppl 1): 979–980. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436399/
10. Bermúdez Fuentes PM, Magariño Abreus LdR, García San Juan CM. Asociación entre enfermedad periodontal y covid-19. Primera Jornada Científica Virtual de COVID-19 en Cienfuegos [Internet]. 2021 [Citado 20/06/2024]. Disponible en: https://cibamanz2021.sld.cu/index.php/cibamanz/cibamanz2021/paper/viewFile/65/124
11. Sehirli AO, Aksoy U, Koca-Ünsal RB, Sayıner S. Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin. Med Hypotheses [Internet]. 2021 [Citado 20/06/2024]; 151: 110588. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33848919/
12. Sánchez Sánchez RJ, Sigcho Romero CR, Niño Peña A. Una díada de riesgo: periodontitis y COVID-19. Gaceta Médica Espirituana [Internet]. 2022 [Citado 20/06/2024]; 24(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1608-89212022000200014
13. Takahashi Y, Watanabe N, Kamio N, Yokoe S, Suzuki R, Sato S, et al. Expression of the SARS-CoV-2 Receptor ACE2 and Proinflammatory Cytokines Induced by the Periodontopathic Bacterium Fusobacterium nucleatum in Human Respiratory. International Journal of molecular Sciences [Internet]. 2021 [Citado 20/06/2024]; 22(3): 1352. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33572938/
14. Baltazar-Díaz T, Zamora-Pérez A. Enfermedad periodontal y COVID-19: factores de riesgo y mecanismos compartidos. Revista Mexicana de Periodontología [Internet]. 2021 [Citado 20/06/2024]; 12(1-3): 12-17. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=102954&id2=
15. Bao , Zhang C, Dong J, Zhao L, Sun J. Oral Microbiome and SARS-CoV-2 Beware of Lung Co-infection. Frontiers in Microbiology [Internet]. 2020 [Citado 20/06/2024]; 11:1840. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32849438/
16. Patel J, Woolley J. Necrotizing periodontal disease: Oral manifestation of. Oral Diseases [Internet]. 2021 [Citado 20/06/2024]; 27(Suppl 3): 768–769. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301037/
17. Sena K, Furue K, Setoguchi F, Noguchi K. Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E 2 in human gingival fibroblasts. Arch Oral Biol [Internet]. 2021 [Citado 20/06/2024]; 129: 105201. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34174588/
18. Zerón A. El coronavirus se ha hecho viral. Revista ADM [Internet]. 2020 [Citado 20/06/2024]; 77(2): 58-61. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=93096
19. Ejaz , Alsrhani A, Zafar , Javed H, Junaid K, Abdalla E, et al. COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of Infection and Public Health [Internet]. 2020 [Citado 20/06/2024]; 13(12): 1833-1839. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32788073/
20. Patrick T, Zhang H, Wasikowski R, Prens P, Weidinger S, Gudjonsson E. Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies. American Academy of Allergy, Asthma & Immunology [Internet]. 2021 [Citado 20/06/2024]; 147(3): 857-869.e7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33485957/
21. Escobar Arregocés FM. COVID-19 su patogenia y relación con enfermedades sistémicas como la enfermedad cardiovascular y la diabetes: ¿Podría la enfermedad periodontal aportar en esta realción?. JPAPO [Internet]. 2020 [Citado 20/06/2024]; 4(1): 39-43.Disponible en: https://appo.com.pe/wp-content/uploads/2020/09/ARTICULO_7_2020.pdf
22. Pitones-Rubio , Chávez-Cortez , Hurtado-Camarena A, González-Rascón , Serafín-Higuera N. Is periodontal disease a risk factor for severe COVID-19 illness? Medical Hypotheses [Internet]. 2020 [Citado 20/06/2024]; 144: 109969. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0306987720312846
23. Yang , Zheng Y, Gou , Pu K, Chen , Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International Journal of Infectious Diseases [Internet]. 2020 [Citado 20/06/2024]; 94: 91-95. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32173574/
24. Ioannidou. The Sex and Gender Intersection in Chronic Periodontitis. Frontiers in Public Health [Internet]. 2017 [Citado 20/06/2024]; 5: 189. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543279/
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
