Post-extraction tissue regeneration with collagen dressing in a controlled diabetic patient
Keywords:
DIABETES, TISSUE REPAIR, COLLAGEN.Abstract
Introduction: diabetes mellitus affects people's health, altering physiological processes such as wound healing, sometimes requiring the use of collagen dressings to repair tissue structure and functionality.
objective: to describe a case of a diabetic patient who was eligible for the use of collagen dressings for post-extraction tissue repair.
Case presentation: the case of a 70-year-old male patient with various oral conditions is presented. He underwent extraction of teeth 38, 46, and 48. The preoperative phase included antibiotic prophylaxis, blood pressure monitoring, and intra- and extraoral asepsis. During the intraoperative phase, anesthesia was administered, extraction procedures, irrigation, and placement of a collagen dressing, followed by simple suturing, were performed. In the postoperative phase, the sutures were removed after seven days, intraoral photography was performed for post-treatment control, and follow-up appointments were scheduled at seven, 10, and 15 days. The collagen dressing was key in promoting healing, highlighting the importance of structured management and biomedical technologies in treatment success.
Conclusions: the collagen dressing promoted excellent healing in a diabetic patient after tooth extraction, with no complications at 15 days, showing results comparable to the contralateral alveolus, according to radiographic analysis and epithelial observation.
Downloads
References
1. OPS. Perfil de carga de enfermedad por diabetes 2023: Ecuador [Internet]. OPS; 2023 [Citado 20/03/2025]. Disponible en: https://www.paho.org/es/documentos/perfil-carga-enfermedad-por-diabetes-2023-ecuador
2.Varg as Burgoa OA. REGENERACION Y CICATRIZACION. Rev. Act. Clin. Med [Internet]. 2014 [citado 26/03/2025]; 43: 2256-2260. Disponible en: http://revistasbolivianas.umsa.bo/scielo.php?script=sci_arttext&pid=S2304-37682014000400003&lng=es
3. Prieto-Gómez B, Aguirre-Castañeda A, Saldaña-Lorenzo JA, León del Ángel JF, Moya-Simarro A. Síndrome metabólico y sus complicaciones: el pie diabético. Rev. Fac. Med. (Méx.) [Internet]. 2017 Ago [citado 26/03/2025]; 60(4): 7-18. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0026-17422017000400007&lng=es.
4. Bernales Diego M, Caride F, Lewis A, Martin Lagens. Membranas de colágeno polimerizado: consideraciones sobre su uso en técnicas de regeneración tisular y ósea guiadas. Rev Cubana Invest Bioméd [Internet]. 2004 Jun [citado 26/03/2025]; 23(2): 65-74. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002004000200001&lng=es.
5. Sclar AG. Strategies for management of single-tooth extraction sites in aesthetic implant therapy. J Oral Maxillofac Surg [Internet]. 2004 Sep [citado 26/03/2025]; 62(9 Suppl 2):90-105. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15332186/
6. Wang HL, Tsao YP. Mineralized bone allograft-plug socket augmentation: rationale and technique. Implant Dent [Internet]. 2007 Mar [citado 26/03/2025]; 16(1): 33-41. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17356370/
7. Piaggio Bravo LA, Sacsaquispe Contreras SJ. Comparación histológica de la reparación ósea alveolar post-exodoncia utilizando una membrana colágena tipo esponja y un material de sulfato de calcio. Revista Estomatológica Herediana [Internet]. 2008 [citado 26/03/2025]; 18(2): 93-98. Recuperado de: https://www.redalyc.org/articulo.oa?id=421539350004
8. Araújo MG, Lindhe J. Ridge preservation with the use of Bio-Oss collagen: A 6-month study in the dog. Clin Oral Implants Res [Internet]. 2009 May [citado 26/03/2025]; 20(5): 433-40. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19522974/
9. Oliveira SH, Soares MJ, Rocha Pde S. Uso de cobertura com colágeno e aloe vera no tratamento de ferida isquêmica: estudo de caso [Use of collagen and Aloe vera in ischemic wound treatment: study case]. Rev Esc Enferm USP [Internet]. 2010 Jun [citado 26/03/2025]; 44(2): 346-51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20642045/
10. Garcia Perez R, Munitiz V, Martinez Caceres CM, Ruiz de Angulo Ortiz, Martinez de Haro LF, et al. Analisis histopatológico e inmunohistoquímico del uso del aposito de colágeno como refuerzo de anastomosis esofágica en un modelo experimental en rata. Cirugía Española [Internet]. 2017 [citado 26/03/2025]; 95(10): 588-593. Disponible en: https://www.elsevier.es/es-revista-cirugia-espanola-36-articulo-analisis-histopatologico-e-inmunohistoquimico-del-S0009739X17301859
11. Kim DM, Lim HC, Hong JY, Shin SI, Chung JH, Herr Y, Shin SY. Validity of Collagen Plugs for Ridge Preservation in a Canine Model. Implant Dent [Internet]. 2017 Dec [citado 26/03/2025]; 26(6): 892-898. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29120890/
12. Altamirano Arcos C, Martínez Wagner R, Chávez Serna E, Altamirano Arcos C, Espino Gaucin I, Nahas Combina L. Cicatrización normal y patológica: una revisión actual de la fisiopatología y el manejo terapéutico. Revista Argentina de Cirugía Plástica [Internet]. 2019Dec [citado 26/03/2025]; 25(1): 11-15. Disponible en: https://adm.meducatium.com.ar/contenido/articulos/20600110015_1512/pdf/20600110015.pdf
13. Irinakis T. Rationale for Socket Preservation after Extraction of a Single-Rooted Tooth when Planning for Future Implant Placement. J Can Dent [Internet]. 2006 [citado 26/03/2025]; 72(10): 917-922. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17187706/
14. Gomez Restrepo LA, Cruz Lozano WJ, Castro Campos S, Muñoz Ramírez AL. Uso de Plasma rico en factores de crecimiento en el tratamiento de úlceras crónicas de pacientes diabeticos. Piel [Internet]. 2017 [citado 26/03/2025]; 32(4): 234-241. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8936661
15. Fajardo Puig ME, Rodríguez Reyes O, Hernández Cunill M, Mora Pacheco N. Diabetes mellitus y enfermedad periodontal: aspectos fisiopatológicos actuales de su relación. MEDISAN [Internet]. 2016 Jun [citado 2025 Mar 25]; 20(6): 845-850. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192016000600014&lng=es.
16. Okonkwo UA, DiPietro LA. Diabetes and Wound Angiogenesis. Int J Mol Sci [Internet]. 2017 Jul 3 [citado 25/03/2025]; 18(7): 1419. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC5535911/
17. González Tuero Jaime Humberto. Medicamentos no tradicionales en el tratamiento de pacientes con heridas que curan por segunda intención. MEDISAN [Internet]. 2014 Nov [citado 26/03/2025]; 18(11): 1603-1610. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192014001100016&lng=es.
18. Kasiewicz LN, Whitehead KA. Recent advances in biomaterials for the treatment of diabetic foot ulcers. Biomater Sci [Internet]. 2017 Sep 26 [citado 26/03/2025]; 5(10): 1962-1975. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28829074/
19. Gantwerker EA, Hom DB. Skin: histology and physiology of wound healing. Facial Plast Surg Clin North Am [Internet]. 2011 Aug [citado 26/03/2025]; 19(3): 441-53.Disponible en: https://pubmed.ncbi.nlm.nih.gov/21856533/
20. Velnar T, Bailey T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res [Internet]. 2009 Sep-Oct [citado 26/03/2025]; 37(5): 1528-42. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19930861/
21. Ranganathan M, Balaji M, Krishnaraj R, Narayanan V, Thangavelu A. Assessment of Regeneration of Bone in the Extracted Third Molar Sockets Augmented Using Xenograft (CollaPlugTN Zimmer) in Comparison with the Normal Healing on the Contralateral Side. J Pharm Bioallied Sci [Internet]. 2017 Nov [citado 26/03/2025]; 9(Suppl 1): S180-S186.Disponible en: https://pubmed.ncbi.nlm.nih.gov/29284960/
22. JIMÉNEZ CE. Curación avanzada de heridas. Revista Colombiana de Cirugía [Internet]. 2008 [citado 26/03/2025]; 23(3): 146-155. Disponible en: http://www.scielo.org.co/pdf/rcci/v23n3/v23n3a4.pdf
23. Wu S, Applewhite AJ, Niezgoda J, Snyder R, Shah J, Cullen B, et al. Oxidized Regenerated Cellulose/Collagen Dressings: Review of Evidence and Recommendations. Adv Skin Wound Care [Internet]. 2017 Nov [citado 26/03/2025]; 30(11S Suppl 1): S1-S18. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29049055/
24.Abdelaziz M, Shaaban R, Abdelhalim S, Sadaka M. EFFECT OF COLLAPLUG® ON THE HEALING OF EXTRACTION SOCKETS IN PATIENTS UNDER ORAL ANTICOAGULANT THERAPY (CLINICAL STUDY). Alexandria Dental Journal [Internet]. 2015 [citado 26/03/2025]; 40(2): 166-172. Disponible en: https://adjalexu.journals.ekb.eg/article_59145.html
25. kakarla P, Sankar Avula JS, Anche S. COLLAGEN AS A BIOMATERIAL IN DENTISTRY. International Journal of Innovative Medicine and Health Science [Internet]. 2016 [citado 26/03/2025]; 6: 1-4. Disponible en: https://www.researchgate.net/publication/298728840_COLLAGEN_AS_A_BIOMATERIAL_IN_DENTISTRY
26. González Aparicio MT, Jara Moreno LM. APLICACIONES CLÍNICAS DE LA FIBRINA RICA EN PLAQUETAS EN ODONTOLOGÍA: REVISIÓN NARRATIVA [Internet]. UNIVERSIDAD EL BOSQUE. Bogota; 2021 [citado 26/03/2025]. Disponible en: https://repositorio.unbosque.edu.co/server/api/core/bitstreams/fb7a3b75-1a60-4ed6-aa5f-9707f09e7096/content
27. Mahesh L, Venkataraman N, Shukla S, Prasad H, Kotsakis GA. Alveolar ridge preservation with the socket-plug technique utilizing an alloplastic putty bone substitute or a particulate xenograft: a histological pilot study. J Oral Implantol [Internet]. 2015 [citado 26/03/2025]; 41(2): 178-83. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23772806/
28. Lázaro-Martínez JL, García-Morales E, Beneit-Montesinos JV, Martínez-de-Jesús FR, Aragón-Sánchez FJ. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. Cir Esp [Internet]. 2007 Jul [citado 26/03/2025]; 82(1): 27-31. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17580028/
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms: Authors will retain their copyrights and grant the journal the right of first publication of their work, which will be publication of their work, which will be simultaneously subject to the Creative Commons Attribution License (CC-BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g.: deposit it in an institutional telematic archive or publish it in a volume). Likewise, and according to the recommendations of the Medical Sciences Editorial (ECIMED), authors must declare in each article their contribution according to the CRediT taxonomy (contributor roles). This taxonomy includes 14 roles, which can be used to represent the tasks typically performed by contributors in scientific academic production. It should be consulted in monograph) whenever initial publication in this journal is indicated. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which may produce interesting exchanges and increase citations of the published work. (See The effect of open access). https://casrai.org/credit/
