Porphyromonas gingivalis in relation to Alzheimer's disease
Keywords:
PERIODONTAL DISEASE, ALZHEIMER'S, PORPHYROMONAS GINGIVALIS, ORAL PATHOLOGY.Abstract
Introduction: periodontal disease is a multifactorial and inflammatory condition and in recent years one of these bacteria has been linked to the development of Alzheimer's disease.
Objective: to describe the relationship between periodontal disease, Porphyromonas gingivalis and Alzheimer's disease.
Methods: a bibliographic, documentary, exploratory, non-experimental, qualitative, qualitative research was carried out by searching for articles in pages such as: Pubmed, Scielo through the Google Scholar search engine. The PRISMA method for systematic reviews was used, with MeSH terms, accompanied by Boolean terms (And, Or, Not). The documents found through the search in digital databases are selected by inclusion and exclusion criteria from 2010 to 2023 because the information was scarce on the subject.
Development: porphyromona gingivalis present in periodontal disease has the ability to be transported with saliva to a more subgingival location, this in turn can directly invade the brain through the bloodstream or via cranial nerves, secreting gingipains which are toxins that cause precursor proteins of Alzheimer's disease to be produced. Porphyromonas gingivalis produces high levels of cytokines, chemokines and systemic tumor necrosis factor, which in turn leads to overproduction and ultimately neurotoxicity.
Conclusions: despite all available scientific evidence indicating that periodontal disease is related to Alzheimer's disease, it has not been possible to date to determine the mechanisms involved.
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